HL Flashcards
1
Q
Non Hodgkin Lymphoma is classified as either
A
- B or T Cell
- Location within germinal line (how differentiated it is)
- High or Low Grade
2
Q
Dark Zone
A
location of somatic mutations; leading to antigen specificity (ideally wanting to get more specific antibody for antigen
3
Q
Light Zone
A
Determination if mutation is more specific
if not leads to apoptosis
4
Q
Three types of NHL
A
- Diffuse Large B Cell Lymphoma
- Burkitt Lymphoma - High Grade
- Follicular Lymphoma - Low Grade
5
Q
Low Grade
A
Follicular Lymphoma
6
Q
High Grade
A
Burkitt Lymphoma
7
Q
NHL is associated with what chromosome
A
14; associated with class switching
8
Q
Germinal Center Markers
A
CD 10
BcL-6
9
Q
High Grade: Burkitt Lymphoma
A
- All cases MYC onogene t(8,14) to IgH
- High proliferative index
- increased with HIV and with areas of malaria
- proliferating so fast leading to apoptosis
10
Q
High Grade Markers
A
CD 10, Bcl6+
MUM1- and Ki67+
11
Q
Proliferative index
A
Ki67
12
Q
Treatment with
A
Anti CD 20
