HIV Therapy Flashcards
1
Q
Currently Available Antirteroviral Classes
A
• Reverse Transcriptase Inhibitors
- Nucleoside/nucleotide analogues
- Non-nucleoside analogues
- Protease Inhibitors
- Attachment Inhibitors
- Integrase Strand Transfer Inhibitors
2
Q
NRTIs
A
3
Q
NNRTIs
A
4
Q
Nucleoside Monophosphate - TDF
A
5
Q
Nucleoside Monophosphate - TAF
A
6
Q
Protease Inhibitors
A
7
Q
INSTIs
A
8
Q
HIV 1 Attachment Inhibitors
A
9
Q
Fusion Inhibition
A
10
Q
Ibalizumab
A
11
Q
Fostemsavir
A
12
Q
When to Start
A
13
Q
What to Start
A
•INSTI + 2 nucleotide (nucleoside) analogues
OR
•Protease Inhibitor + 2 nucleotide (nucleoside) analogues
14
Q
Goals of Antiretroviral Therapy
A
- Within 6 weeks, plasma HIV RNA should have declined by >1 log
- By six months, HIV RNA should be undetectable (<50 copies/ml)
- CD4 cell count will rise with suppression of HIV RNA
15
Q
The Problem of Viral Latency
A
- ART suppresses all actively replicating virus BUT
- There are reservoirs of non-replicating HIV-1 that are not susceptible to ART
- When ART is stopped, these reservoirs cause new active replication
- Recent data suggest that this reservoir is 60-fold larger than previously thought