HIV drugs

Question 1

How many types of HIV drugs are there? Name the types. (4)

Answer 1

1) Reverse transcriptase inhibitors
2) Protease inhibitors
3) Binding and Fusion inhibitors
4) Integras inhibitors (IIs)

Question 2

Reverse transcriptase inhibitors - moa and examples? (2)

Answer 2

MOA: Inhibits virus multiplication
Ex: Nucleoside/nucleotide: NRT1
-Non-nucleoside: NNRTI

-NRTIs were 1st group of antiretroviral drug approved for use in HIV/AIDs patients

Question 3

Protease inhibitors - moa and examples (1)

Answer 3

MOA: (PI-protease inhibitors) inhibit viral multiplication
Ex: Highly Active AntirRetroviral Treatment (HAART)
-1+2 given together - RT inhibitor plus PI

Question 4

Binding and Fusion inhibitors - moa and examples (2)

Answer 4

MOA: binding and fusion inhibitor
Ex: Enfuvirtide-blocks action of gp41
-Maraviroc blocks CCR5

-Enfuvirtide is a 36 amino acid peptide that mimics one section of gp41

Question 5

Integrase inhibitors (IIs) - moa and example (1)

Answer 5

MOA: inhibit latency
Ex: Isentress

Question 6

Multiple drug therapy - why is it needed?

Answer 6

To minimize the emergence of resistance - virus mutates fast