HIV clinical

Question 1

Can CD4 count be used for HIV diagnosis?

Answer 1

no, CD4 alone should not. if you have sepsis, your CD4 count may drop down to 100.

Question 2

what is a cut off of CD4 count for HIV clinical infection?

Answer 2

200

Question 3

what kind of skin dz can you get with HIV?

Answer 3

1. seborrheic dermatitis

2. papulopruritic eruptions nodular prurigo

Question 4

what is the CD4 account when skin dz occur with HIV?

Answer 4

about 500

Question 5

what is the CD4 account when pulmonary TB?

Answer 5

about 300

Question 6

what is the characteristics of TB in AIDS pt?

Answer 6

TB can be found in anywhere in the lung (not just at the apex)

Question 7

what causes oral luekoplakia?

Answer 7

herpes

Question 8

oral thrush?

Answer 8

candida albicans

Question 9

what is kaposi’s sarcoma?

Answer 9

blood vessel tumor

Question 10

what is the most common serious dz with AIDS?

Answer 10

PCP –> now called Pneumocystis jirovecii –> responds best to Sulfar drug

Question 11

what do you see from pt with PCP in AIDS?

Answer 11

lymphadenopathy

Question 12

what is esophageal Candida?

Answer 12

thrush extended to esophagus?

Question 13

herpes can lead to

Answer 13

facial lesion

Question 14

toxoplasmosis?

Answer 14

multiple ring enhancing on MRI, usually associated with basal ganglia

Question 15

JC Virus can cause

Answer 15

Progressive Multifocal leukoencephalopathy

Question 16

CMV can cause

Answer 16

Retinitis

Question 17

what is Mycobacterium avium-intracellulare

Answer 17

MAI or MAC, a dz of advanced HIV

Question 18

what is the goal of Antiretrovial therapy?

Answer 18

to suppress HIV-1 replication –> prevent/delay destruction of immune system –> achieve normal survival

Question 19

if the viral load is NOT high but CD4 count is 350

Answer 19

defer therapy

Question 20

what are the reasons to delay HAART?

Answer 20

1. toxicities
2. resistance to drugs
3. cost
4. non-adherernce

Question 21

What is the intial HAART?

Answer 21

2 nucleoside + 1 PI or 2 necleoside + 1 integrase inhibitor