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ABX - Adverse side effects > HIV antivirals > Flashcards

HIV antivirals Flashcards

1
Q

What is TDF?

A

Tenofivir and disoproxil furmarate

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2
Q

What is TAF?

A

Tenofivir and alafenamide

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3
Q

What adverse reaction does TDF have?

A

Renal

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4
Q

What do you give for PrEP or PEP?

A

Emtricitabine and TDF (Truvada) or

Emtricitabine and TAF (Descovy)

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5
Q

What are TDF and TAF?

A

Dual nuke backbones

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6
Q

What is Truvada?

A

Emtricitabine and TDF

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7
Q

What is Descovy?

A

Emtricitabine and TAF

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8
Q

What is a side effect of emtricitabine?

A

Hyperpigmentation of palms (DDX syphillis)

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9
Q

What causes hyperpigmentation of the skin?

A

Emtricitabine

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10
Q

What are other names for Zidovudine?

A

AZT, Retrovir

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11
Q

What is a specific use for Zidovudine?

A

Prevention of vertical transmission in pregnancy when viral load is over 400

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12
Q

What are some adverse reactions of Zidovudine?

A

Bone marrow suppression / macrocytic anemia is almost universal

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13
Q

What are the precautions of using Lamivudine?

A

It has both HIV and HBV dosing.

Needs to be given with abacavir.

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14
Q

What is Triumeq?

A

Dolutegravir / abacavir / lamivudine

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15
Q

What is Genvoya?

A

Evlitegrivir / cobicistat / tenofivir alafenamide / emtricitabine

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16
Q

What is Stribild?

A

Elvitegrivir / cobicistat / tenofivir disoproxil fumarate / emtricitabine

17
Q

What is Atripla?

A

Efavirenz / tenofivir disproxil fumarate / emtricitabine

18
Q

Elvitegrivir / cobicistat / tenofivir alafenamide / emtricitabine

A

Genvoya

19
Q

Elvitegrivir / cobicistat / tenofivir disoproxil fumarate / emtricitabine

A

Stribild

20
Q

Efavirenz / tenofivir disproxil fumarate / emtricitabine

A

Atripla

21
Q

Dolutegravir / abacavir / lamivudine

A

Triumeq

22
Q

Drawbacks of using efaviranz

A

Taken HS (at bedtime)
+ cannabinoid test
Not initial therapy

23
Q

Rilpivirine drawbacks

A

Not for high viral loads over 100,000

Avoid PPI’s, need acid to work

24
Q

Name two protease inhibitors

A

Atazanivir and Darunivir

25
Q

What is a drawback to using Darunivir?

A

Sulfa allergy or sulfa related rash

26
Q

What are drawbacks to using Atazanivir?

A

PPI’s must be change to 20 mg one-razored 12 hrs later

Hyperbilirubinemia is almost universal

27
Q

Name two integrase inhibitors

A

Raltegrivir and Dolutegrivir

28
Q

Drawbacks to raltegrivir

A

Increased CK
BID
Must take dual backbone separately

ABX - Adverse side effects (8 decks)

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