HIV antivirals Flashcards
What is TDF?
Tenofivir and disoproxil furmarate
What is TAF?
Tenofivir and alafenamide
What adverse reaction does TDF have?
Renal
What do you give for PrEP or PEP?
Emtricitabine and TDF (Truvada) or
Emtricitabine and TAF (Descovy)
What are TDF and TAF?
Dual nuke backbones
What is Truvada?
Emtricitabine and TDF
What is Descovy?
Emtricitabine and TAF
What is a side effect of emtricitabine?
Hyperpigmentation of palms (DDX syphillis)
What causes hyperpigmentation of the skin?
Emtricitabine
What are other names for Zidovudine?
AZT, Retrovir
What is a specific use for Zidovudine?
Prevention of vertical transmission in pregnancy when viral load is over 400
What are some adverse reactions of Zidovudine?
Bone marrow suppression / macrocytic anemia is almost universal
What are the precautions of using Lamivudine?
It has both HIV and HBV dosing.
Needs to be given with abacavir.
What is Triumeq?
Dolutegravir / abacavir / lamivudine
What is Genvoya?
Evlitegrivir / cobicistat / tenofivir alafenamide / emtricitabine
What is Stribild?
Elvitegrivir / cobicistat / tenofivir disoproxil fumarate / emtricitabine
What is Atripla?
Efavirenz / tenofivir disproxil fumarate / emtricitabine
Elvitegrivir / cobicistat / tenofivir alafenamide / emtricitabine
Genvoya
Elvitegrivir / cobicistat / tenofivir disoproxil fumarate / emtricitabine
Stribild
Efavirenz / tenofivir disproxil fumarate / emtricitabine
Atripla
Dolutegravir / abacavir / lamivudine
Triumeq
Drawbacks of using efaviranz
Taken HS (at bedtime)
+ cannabinoid test
Not initial therapy
Rilpivirine drawbacks
Not for high viral loads over 100,000
Avoid PPI’s, need acid to work
Name two protease inhibitors
Atazanivir and Darunivir
