HIV Antiretroviral Agents

Question 1

Nucleoside Reverse Transcriptase Inhibitors

NRTIs

Answer 1

Brand: Tenofovir Alafenamide

Generic: None

Code: TAF

Food:

TOD:

Dose Adj: Renal

Major ADR: Lactic Acidosis, Hepatic Steatosis, HBV flare (w/ DC)

Question 2

Nucleoside Reverse Transcriptase Inhibitors

NRTIs

Answer 2

Brand: Viread

Generic: Tenofovir Disoproxil Fumarate

Code: TDF

Food:

TOD:

Dose Adj: Renal

Major ADR: Lactic Acidosis, Hepatic Steatosis, HBV flare (w/ DC), Nephrotoxicity, Osteopenia

Question 3

Nucleoside Reverse Transcriptase Inhibitors

NRTIs

Answer 3

Brand: Emtriva

Generic: Emtricitabine

Code: FTC

Food:

TOD:

Dose Adj: Renal

Major ADR: Lactic Acidosis, Hepatic Steatosis, HBV flare (w/ DC)

Question 4

Nucleoside Reverse Transcriptase Inhibitors

NRTIs

Answer 4

Brand: Epivir

Generic: Lamivudine

Code: 3TC

Food:

TOD:

Dose Adj: Renal

Major ADR: Lactic Acidosis, Hepatic Steatosis, HBV flare (w/ DC)

Question 5

Nucleoside Reverse Transcriptase Inhibitors

NRTIs

Answer 5

Brand: Ziagen

Generic: Abacavir

Code: ABC

Food:

TOD:

Dose Adj: Hepatic

Major ADR: Lactic Acidosis, Hepatic Steatosis, HLA-B*5701 hypersensitivity, CV risk

Question 6

Nucleoside Reverse Transcriptase Inhibitors

NRTIs

Answer 6

Brand: Zidovudine

Generic: None

Code: AZT

Food:

TOD:

Dose Adj: Renal

Major ADR: Lactic Acidosis, Hepatic Steatosis, Cytopenias

Question 7

Non-Nucleoside Reverse Transcriptase Inhibitors

NNRTIs

Answer 7

Brand: Sustiva

Generic: Efavirenz

Code: EFV

Food: w/o bc dec ADR

TOD: Night bc dc AM ADR

Dose Adj: Hepatic

Major ADR: Rash, Hepatotxicity, CNS Effects

Question 8

Non-Nucleoside Reverse Transcriptase Inhibitors

NNRTIs

Answer 8

Brand: Edurant

Generic: Rilpivirine

Code: RPV

Food: w/ bc inc Abs

TOD:

Dose Adj: Renal, Hepatic

Major ADR: Rash, Hepatotxicity, Renal Virologic Response (Low VL/CD4), Depression, QTc prolongation

Question 9

Non-Nucleoside Reverse Transcriptase Inhibitors

NNRTIs

Answer 9

Brand: Intelence

Generic: Entravirine

Code: ETR

Food: w/ bc inc Abs

TOD:

Dose Adj: Hepatic

Major ADR: Rash, Hepatotxicity, Inc Lipids, Inc Glucose

Question 10

Non-Nucleoside Reverse Transcriptase Inhibitors

NNRTIs

Answer 10

Brand: Viramune

Generic: Nevirapine

Code: NVP

Food:

TOD:

Dose Adj: Hepatic

Major ADR: Rash, Hepatotxicity, Rash/Hepatotoxicity Contraindications (based on Gender and CD4 Count)

Question 11

Protease Inhibitors

PIs

Answer 11

Brand: Prezista

Generic: Darunavir

Code: DRV

Food: w/ dec GI upset

TOD:

Dose Adj: Hepatic

Major ADR: Hyperglycemia, Hyperlipidemia, Hepatotoxicity, Nausea/GI Upset, Rash

Question 12

Protease Inhibitors

PIs

Answer 12

Brand: Reyataz

Generic: Atazanavir

Code: ATV

Food: w/ inc Abs

TOD:

Dose Adj: Renal, Hepatic

Major ADR: Hyperglycemia, Hyperlipidemia, Hepatotoxicity, Hyperbilirubinemia

Question 13

Protease Inhibitors

PIs

Answer 13

Brand: Kaletra

Generic: Lopinavir/Ritonavir

Code: LPV/r or LPV/RTV

Food:

TOD:

Dose Adj: Hepatic

Major ADR: Hyperglycemia, Hyperlipidemia, Hepatotoxicity, Diarrhea

Question 14

Protease Inhibitors

PIs

Answer 14

Brand: Lexiva

Generic: Fosamprenavir

Code: FPV

Food:

TOD:

Dose Adj: Hepatic

Major ADR: Hyperglycemia, Hyperlipidemia, Hepatotoxicity, Diarrhea

Question 15

Integrase Inhibitors

INSTIs

Answer 15

Brand: Tivicay

Generic: Dolutegravir

Code: DTG

Food:

TOD:

Dose Adj: Renal, Hepatic

Major ADR: Inc SCr (non-toxic)

Question 16

Integrase Inhibitors

INSTIs

Answer 16

Brand: Vitekta

Generic: Elvitegravir

Code: EVG

Food: w/ dec GI

TOD:

Dose Adj: Hepatic

Major ADR: Nausea, GI Upset

Question 17

Integrase Inhibitors

INSTIs

Answer 17

Brand: Isentress

Generic: Raltegravir

Code: RAL

Food:

TOD:

Dose Adj: Hepatic

Major ADR: Myopathy (inc CPK)