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Immunology > HIV and HAART > Flashcards

HIV and HAART Flashcards

1
Q

HAART agents causing peripheral neuropathy

A

Didanosine, Stavudine, Zalcitabine

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2
Q

MOA of raltegravir

A

Integrase inhibitor

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3
Q

NOD like receptor responsible for gout

A

NALP3

Caspase 1 activated and IL-1 beta released

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4
Q

DOC for HIV, Hep B coninfection not on HAART

A

Emtricitabine+Tenofovir with NNRTI or PI
On HAART - Truvada or Lamivudine +Tenofovir(Lamivudine naïve)
Entacavir only if full suppression of HIV
If on Lamivudine -Add Tenofovir/adefovir or change to Truvada

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5
Q

HAART agent causing lipodystrophy

A

Ritonavir

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6
Q

Complication of statin with protease inhibitor

A

Protease inhibitors cause CYP3A4 inhibition
Can cause high statin levels leading to rhabdomyolysis
Alternative -Pravastatin

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7
Q

Drug absolutely CI with PI

A

Cisapride -can cause torsades

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8
Q

Cytokines mediating atopy

A

Th2 response
IL-4, 13 -Act on B cells to cause Ig E switching
IL-5 attracts eosinophils

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9
Q

Exposure posing highest risk of HIV transmission

A

Receptive anal intercourse -1/120

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10
Q

S/E of tenofovir

A

Renal impairment, osteoporosis

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11
Q

HLA related to abacavir hypersensitivity

A

HLA B5701

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12
Q

HAART causing lipoatrophy

A

Zidovudine, stavudine

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13
Q

S/E of PI

A

Insulin resistance, hyperlipidemia, increased CV risk

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14
Q

MOA of MARAVIROC

A

CCR5 inhibitor

Not active in patients where virions use CXCR4 for entry

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15
Q

Strongest single predictor of disease progression at all stages of HIV

A

CD38 expression by CD8 cells

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16
Q

HAART causing indirect hyperbilirubinema

A

Atazanavir

17
Q

Most powerful predictor of progression to AIDS

A

CD4 counts

18
Q

Risk of transmission of HIV in pregnancy with HAART

A

<1%

Without HAART-10%

19
Q

Characteristic of R5 strain of HIV

A

Most frequently transmitted
Less aggressive
Uses CXCR5 for entry
Infects macrophages and T cells

20
Q

Characteristic of X4 strain of HIV

A

More aggressive

Uses CXCR4 for entry

21
Q

Characteristic of HIV-2

A

Less virulent
Lower viral load
Less vertical transmission
Western central Africa and India

22
Q

HIV modification of HBV

A 
Higher rate of chronic infection 
Lower HbeAg seroconversion 
Higher HbeAg
Higher DNA levels
Less necroinflammation , more faster progression to cirrhosis
23
Q

Effect of hererozygosity for CCR5 delta 32

A

Slower progression to AIDS by two fold

24
Q

Test most useful for confirming reaction to contrast media within 2 hrs

A

Tryptase

Contrast media - non IgE mediated reaction

25
Q

HAART causing nephrolithiasis

A

Indinavir

Atazanavir

26
Q

Entry of HIV into host cell occurs via which protein

A

gp120

27
Q

HAART drug causing pancreatitis

A

Didanosine

28
Q

Characteristic feature of acute HIV-1 infection

A

Painful mucocutaneous ulcers

29
Q

HAART drug causing high risk of MI

A

Abacavir

Lopinavir/Ritonavir

Immunology (11 decks)

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