HIV and HAART Flashcards
HAART agents causing peripheral neuropathy
Didanosine, Stavudine, Zalcitabine
MOA of raltegravir
Integrase inhibitor
NOD like receptor responsible for gout
NALP3
Caspase 1 activated and IL-1 beta released
DOC for HIV, Hep B coninfection not on HAART
Emtricitabine+Tenofovir with NNRTI or PI
On HAART - Truvada or Lamivudine +Tenofovir(Lamivudine naïve)
Entacavir only if full suppression of HIV
If on Lamivudine -Add Tenofovir/adefovir or change to Truvada
HAART agent causing lipodystrophy
Ritonavir
Complication of statin with protease inhibitor
Protease inhibitors cause CYP3A4 inhibition
Can cause high statin levels leading to rhabdomyolysis
Alternative -Pravastatin
Drug absolutely CI with PI
Cisapride -can cause torsades
Cytokines mediating atopy
Th2 response
IL-4, 13 -Act on B cells to cause Ig E switching
IL-5 attracts eosinophils
Exposure posing highest risk of HIV transmission
Receptive anal intercourse -1/120
S/E of tenofovir
Renal impairment, osteoporosis
HLA related to abacavir hypersensitivity
HLA B5701
HAART causing lipoatrophy
Zidovudine, stavudine
S/E of PI
Insulin resistance, hyperlipidemia, increased CV risk
MOA of MARAVIROC
CCR5 inhibitor
Not active in patients where virions use CXCR4 for entry
Strongest single predictor of disease progression at all stages of HIV
CD38 expression by CD8 cells
HAART causing indirect hyperbilirubinema
Atazanavir
Most powerful predictor of progression to AIDS
CD4 counts
Risk of transmission of HIV in pregnancy with HAART
<1%
Without HAART-10%
Characteristic of R5 strain of HIV
Most frequently transmitted
Less aggressive
Uses CXCR5 for entry
Infects macrophages and T cells
Characteristic of X4 strain of HIV
More aggressive
Uses CXCR4 for entry
Characteristic of HIV-2
Less virulent
Lower viral load
Less vertical transmission
Western central Africa and India
HIV modification of HBV
Higher rate of chronic infection Lower HbeAg seroconversion Higher HbeAg Higher DNA levels Less necroinflammation , more faster progression to cirrhosis
Effect of hererozygosity for CCR5 delta 32
Slower progression to AIDS by two fold
Test most useful for confirming reaction to contrast media within 2 hrs
Tryptase
Contrast media - non IgE mediated reaction
