Allergy and hypersensitivity Flashcards
1
Q
Most specific test for NSAID HS
A
Basophil activation test
2
Q
Cells involved in early inflammatory phase of IgE mediated allergic response
A
Mast cells
Late phase -eosinophils
3
Q
Acute management of symptoms in HAE
A
C1 Esterase concentrate FFP if above not available Kallikrein inhibitor - Ecallantide Bradykinin inhibitor -Icatibant Prophylaxis -Danazol, tranexemic acid No response to antihistamines/steroids/epinephrine
4
Q
Skin prick testing not useful in allergy to which substance
A
Aspirin
Skin prick testing is used to look at specific IgE
Not useful in anaphlactoid reactions
5
Q
Cytokines in atopy
A
IL-4 acts on naïve T cells to create more Th2 cells
B cells to promote Ig E switching
IL-13 acts on B cells to promote Ig E switching
IL-5 attracts eosinophils
6
Q
Causes of elevated IgE
A
Atopic dermatitis ABPA Parasitic infections Lymphoma -Hodgkins Wiskott-Aldrich Hyper -IgE syndrome Ig E myeloma
7
Q
Location of Ig E receptors
A
FcER1
Mast cells, basophils, activated eosinophils
