Complements

Question 1

Cleavage of which of following components of complement system elicits inflammatory response?

Answer 1

C3

Question 2

Complement activators in alternate pathway

Answer 2

Surface of bacteria,virus, polysaccharides,IgA immune complexes,C3 nephritic factor

Question 3

Complement activators in classical pathway

Answer 3

IgM, IGg, CRP, C1q

Question 4

Complement activation on lectin pathway

Answer 4

MBL, Ficollins 1-3

Question 5

C5 convertase of alternate pathway

Answer 5

C3bBb3b

Question 6

C5 convertase of classical pathway

Answer 6

C4bC2b

Question 7

Which are anaphylatoxins

Answer 7

C3a, C5a

Question 8

Diseases caused by Properdin, Factor D deficiency

Answer 8

Nesisseria infections

Question 9

Disease caused by terminal complement deficiency

Answer 9

Disseminated Neisseria infections

Question 10

Cause of hereditary angioedema

Answer 10

Hemizygous deficiency of C1 esterase inhibitor

Increased classical complement activation ->increased bradykinin release -> oedema

Question 11

Gene coding for C1 esterase inhibitor

Answer 11

SERPING 1 gene

Question 12

Types of HAE

Answer 12

Reduced C4, Normal C3,C1q always normal in HAE
Type 1 -marked reduction in C1-INH level
Type 2 - C1-INH N or high -dysfunctional protein

Question 13

Types of acquired C1-inhibitor deficiency

Answer 13

Type 1-consumption of C1-INH- eg B cell lymphoproliferative disorders
Type II - Autoab against C1-INH, eg Idiopathic/ AI disease