HIV

Question 1

How does the HIV virus attach to helper T Cells?

Answer 1

Gp 120 binds directly with the CD4 receptor and the ccr5 and cxcr4 help it bind

Question 2

How does the HIV virus take over the helper T cell?

Answer 2

Virus fuses with cell memebrane and releases RNA. A DNA copy is then made from the RNA by reverse transcriptase. RNAseH separates the DNA from RNA and DNA is taken up into the nucleus. Integrase opens the host DNA and puts the HIV DNA in

Question 3

What occurs if the HIV DNA is not put near the transcription factor?

Answer 3

The cell is latently infected

Question 4

What occurs once the virus has infected the T Cell?

Answer 4

It reassembles then buds off the cell and leaves. Protease matures the virus particle

Question 5

What kills the infected T Cell?

Answer 5

Immune response or excessive virus buds

Question 6

When can HIV treatment begin?

Answer 6

When CD4 is less than 500

Question 7

What are the stages of HIV infection?

Answer 7

Seroconversion illness
Asymptomatic illness (6-8 years)
Late stage HIV

Question 8

What are the four drugs to treat HIV and what do they target?

Answer 8

Enfurvitide- fusion
Tenofavir- reverse transcriptase
Raltegravir- Integrase
Atazanavir- Protease