Cancer Workshop Flashcards
1
Q
Which immune cells are involved in eliminating cancer cells in healthy people?
A
Natural killer cells
Helper T cells
Cytotoxic T cells
2
Q
How do cancer cells avoid immune system effectors?
A
Reduced HLA class 1 expression Poor immunogenicity Resistance to immune attack Release immune inhibitors Amino acid depletion Releases regulatory T cells
3
Q
How tumour cells use tryptophan to their advantage?
A
They suck it all up so the immune cells die without it
4
Q
What are the two hereditary colorectal cancer syndromes?
A
Familial adenomatous polyposis (FAP)
Non-polyposis colorectal cancer (HNPCC)
5
Q
Which gene is responsible for FAP?
A
APC gene
6
Q
Which genes are responsible for HNPCC?
A
MLH1
MSH2
7
Q
What is the normal loss of genes in colorectal tumours?
A
APC then KRAS then p53
