HIV

Question 1

Lamivudine

Answer 1

N/V/D
Pancreatitis
Fatigue
Reactivation of HBV

Question 2

Emtricitabine

Answer 2

N/V/D
Hyperpigmentation

Question 3

Tenofovir

Answer 3

N/V/D
Dyslipidemia
Impaired bone mineralisation
Renal impairment

Question 4

Abacavir

Answer 4

N/V/D
Risk of hypersensitivity
Dyslipidemia
Risk of MI

Question 5

Zidovudine

Answer 5

N/V/D
Insomnia
Myopathy
Bone marrow suppression
Highest risk of lactic acidosis

Question 6

INSTIs

Answer 6

Weight gain (most)
Depression and suicidality
Increased SCr levels (B, C, D)
Increased CPK (highest with R)
Hyperglycemia (D, E)
Hepatotoxicity (C, D, R)

DDI with polyvalent cations
CYP3A substrates (B, D, E)
DDI with metformin (dolutegravir)

Question 7

Efavirenz

Answer 7

Rash
Risk of SJS
Hyperlipidemia
Neuropsychiatric side effects (dizziness, depression, insomnia, vivid dreams, hallucination)
Hepatotoxicity
QTc prolongation
High resistance rate

CYP3A4 substrate, CYP2B6 & CYP2C19 inducer

Question 8

Rilpivirine

Answer 8

Headache
Depression
QTc prolongation
High resistance rate

CYP3A4 substrate, DDI with increased gastric pH

Question 9

PI

Answer 9

Metabolic dysfunction
N/V/D
Hepatotoxicity
Osteopenia, osteoporosis
CYP3A4 substrate & inhibitor
Lipohypertrophy

Ritonavir: Taste perversion, paresthesia
Darunavir: Rash
Atazanavir: Rash, QTc prolongation, hyperbilirubinemia, reduced absorption with increased GI pH

Question 10

Enfuvirtide

Answer 10

Injection site reactions (pruritus, pain, ecchymosis)
Increased bacterial pneumonia
Hypersensitivity

Question 11

Maraviroc

Answer 11

Rash
Pyrexia
Cough
Increased URTI
Abdominal pain
Hepatotoxicity
Dizziness
Orthostatic hypotension
Musculoskeletal symptoms

CYP3A4 substrate