History Medicine Flashcards
Name six factors for change in medicine.
Government, War, Science/tech, Individuals, Communication, Chance.
What can be said about understanding of disease and the human body in the mid 1800s?
Belief in miasma (bad air) causing disease, and also in spontaneous generation creating disease.
Limited understanding of the body, doctors could only use criminals for dissection, so difficult to study diseases.
What can be said about surgery in the mid 1800s? [6]
- Operations were carried out very fast and patients were awake.
- Only dealt with obvious physical problems on the outside of the body.
- People would often go to their local barber or blacksmith.
- No anaesthetic (trauma and pain)
- Poor hygiene and bad conditions (infection)
- No effective methods to stop blood loss.
Name four developments in anaesthetics.
- In 1846 Liston begins using ether. This did however irritate the lungs and was flammable.
- James Simpson discovered chloroform, and wrote articles about the success. Even Queen Vic used it. People did oppose it because it could be overdosed.
- John Snow invented the chloroform inhaler.
- Deaths rose with anaesthetics because infection was worked deeper into the body in longer surgery. “The black period”.
Describe one feature of the work of Joseph Lister.
Comes up with a carbolic acid spray to sterilise wounds and equipment during surgery. He realises that he is killing germs in the air from Pasteur’s work. The death rate in his work goes from 46% to 15%. Begins to start creating aseptic conditions. By 1890 most doctors used antiseptics.
What changes were made in the sealing of blood vessels? [3]
- Blood vessels usually sealed by cauterisation (painful).
- Liston realised that ligatures carried infection and prevented smooth healing.
- In 1881 Lister uses Catgut, which had fewer infections and dissolved in the body.
How were blood groups discovered? Was there an impact?
- In 1901 Landsteiner discovered A/B/O, 1902 AB. Drs realised that patients had to be given the correct blood type.
- Understanding improved but limited impact because no way of storing blood.
Describe how X-rays were discovered. What was one impact?
- Discovered by Wilhelm Rontgen in 1895. By 1896 many hospitals had machines. Now bullets and shrapnel could be located, which reduced infection.
What were some problems in WW1 that required surgery? [3]
- Gas gangrene infection.
- Broken legs, and shrapnel wounds lead to amputation: 240 000 soldiers lost a limb.
- Head wounds.
What surgical advancements were made during ww1? [4]
- Surgical technique improved.
- Thomas splint invents the splint: survival goes from 20% to 82%.
- Brain surgery attempts.
- Skin graft knowledge develops.
Name a feature of the work of pasteur (germs)
He discovered microorganisms growing in beer and solved the problem by boiling the liquid. The 1860 scientific competition made this theory famous.
Pasteur connected microorganisms to disease after investigating with silkworms.
Name one feature of the work of Koch
He discovered that specific microorganisms cause specific diseases. He focuses on the anthrax bacteria after experimenting with mice.
How did Koch help solve problems with infection?
He discovered that bacteria in the blood caused blood poisoning and recommended that instruments should be sterilised with heat. He published his findings. By the 1880s hospitals become more rigorously cleaned.
Describe one feature of the work of Paul Ehlirch.
He worked on Koch’s research team, reasoned that if certain dyes could stain bacteria, perhaps certain chemicals could kill them.
He developed the first Magic bullet, Salvarsan for syphillis.
Found by chance: Dr Sahachiro Hata found it in the 606th compound.
How did Fleming rediscover penicillin? What was his problem? [4]
He found it on a petri dish in his lab killing the bacteria around it.
He bred enough of it to test it on 8 mice who had deadly streptococci.
He tested it on a human first in 1941, and it worked but ran out.
It was incredibly difficult to produce it in large quantities, and he could not get support or funding.
What did Florey and Chain do to produce penicillin? What factors helped them?
They traveled to the USA, who once the war started gave 80 million to drug companies. Mass production began in 1943. After the war it was made available for civilian use. Technology in mass producing it, and Gov’ support.
What were some of the impacts of penicillin?
It roughly halved the average time wounded Allies spent in hospital.
It could treat many infections and diseases including streptococcus, scarlet fever, and gonorrhoea.
What and when was the second magic bullet?
1932 Gerhard Domalk tried out prontosil which has an effect on blood poisoning. This was supported by the invention of electron microscopes.
How did Koch help improve scientific experimentation? [3]
- He developed ways to stain and examine bacteria - identification.
- Developed a solid medium for growing bacteria.
- He also practiced thorough experimentation technique, e.g. 20 generations of mice for anthrax.