History Flashcards

1
Q

First recorded successful human blood transfusion

A

James Blundell (1818)

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3
Q

Coagulation of blood arise from the upper liquid part of the blood

A

William Hewson (1770/71)

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5
Q

Ambroise Paré

A

Bec de corbin (pinching instrument)

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6
Q

Described a bleeding disorder in several families ( hemophilia)

A

Dr. JC Otto (1803)

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7
Q

1642

A

Antoine van Leeuwenhoek invented microscope

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8
Q

The term “fibrinogen”

A

Babington (1830)

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10
Q

3 classes of animal matter: Gelatine, albumin, and fibrin

A

Antoine Fourcroy (1788)

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11
Q

First successful while blood transfusion to treat hemophilia

A

Samuel Armstrong Lane and Jamed Blundell (1840)

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12
Q

The term “thrombin”

A

Rudolf Virchow (1856)

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13
Q

The term haemorrhaphilia ( haemophilia)

A

Friedrich Hopff and Dr. Schonlein (1828)

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14
Q

Factors that promote blood clot: venous stasis, vascular wall injury, and hypercoagulability; what is this called?

A

Rudolf Virchow (1856); virchow’s triad

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15
Q

2 preparation of fibrinogen by salt precipitation

A

Prosper Sylvian Denis (1859)

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16
Q

Blood staining was developed, ID 3 types of granulocytes, mast cells, polychromatophilia, and megaloblasts

A

Paul Ehrlich (1878)

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18
Q

Bleeding time test

A

William Duke (1910)

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19
Q

Damaged tissue releases plasminogen activator that activates plasminogen to plasmin

A

MacFallane (1937)

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21
Q

Blood circulation

A

William Harvey (1628)

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22
Q

Twisted tourniquet

A

Morel (1674)

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23
Q

Describes thrombosis and Embolism

A

Rudolf Virchow (1868)

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24
Q

“Thrombokimase”

A

Paul Morawitz (1904)

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25
Q

Coagulation is due to a ferment-like substance (thrombin) which exists in circulating blood as an inactive precursor (prothrombin)

A

Alexander Schmidt (1872)

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26
Q

Fibrin is the result of the interaction between thrombin and fibrinogen

A

Olof Hammarsten (1879/80)

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27
Q

Discovered PLTs

A

Guilio Bizzozero (1882)

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28
Q

Discovered heparin

A

Jay McLean (1916)

30
Q

Factor XII

A

Hageman (1955)

31
Q

Calcium precipitants inhibit coagulation but can be reversed when sufficient amount was readded

A

Arthus and Pages (1890)

33
Q

Anti-hemophilic factor (factor VIII)

A

Arthur Patek and FHL Taylor (1937)

34
Q

Role of tissue in converting prothrombin to thrombin (zymoplastic)

A

Schimdt

38
Q

Oxalated plasma

A

Quick (1943)

39
Q

Lab test to evaluate clotting time; name the test; normal value

A

Lee-white whole blood coagulation time; 5-15 min

40
Q

“Tissue factor” for thrombokinase

A

Howell (1914)

41
Q

Ppt fibrinogen: diluted plasma + Acetic acid

A

Mellanby (1909)

42
Q

Dicoumanol was extracted from mouldy sweet clover leaves

A

1939

43
Q

Factor VII

A

Owen and Bollman (1948)

44
Q

Factor IX

A

Stephen Christmas (1952)

45
Q

PT test; other name; normal value

A

Armand Quick; Quick test; 10.3-13.8 seconds

46
Q

Cryoglobulin as an administrable source of factor VII

A

J. Pool

47
Q

Described and illustrated blood Platelets

A

Alexandre Donné (1842)

48
Q

Platelets are derived from megakaryocytes

A

James Wright (1906)

49
Q

Described minute haemorrhages in the skin in cases of allergic purpura

A

Schönlein (1837)

50
Q

1st anticoagulant discovered

A

Sodium citrate

51
Q

Na citrate conc in blood collection for hemostatic procedures

A

3.2%

52
Q

Roman numerals to name factors

A

1954

55
Q

Described RBCs and a meshwork with a fibrous texture (fibrin)

A

Marcello Malphigi (1666)

56
Q

First written reference attributed to human hemophilia

A

Moses Maimonides (2nd Century AD)

58
Q

Studied aniline dye’s selective action on cells and tissues

A

Paul Ehrlich (1877)

59
Q

Devised and published a stain for differential staining of blood cells

A

James Wright (1902)

64
Q

aPTT; normal value

A

RD Langdell, RH Wagner, and KM Brinkhous; 25-43 seconds (1953)

66
Q

Proaccelerin (factor V)

A

Paul Owrner (1947)

67
Q

Father of hematology

A

William Hewson

68
Q

Came up with a purer preparation of fibrinogen due to repeated precipitation with half saturated NaCl

A

Olof Hammersten (1879/80)

70
Q

the term “Fibrin”

A

Antoine Fourcroy

71
Q

“Heparin”

A

Howell and Holt (1918)

72
Q

Presence of nucleated RBCs in the bone marrow sap of humans and rabbits

A

Franz Ernst Christian Neuman (October 1868)

76
Q

4 factors in coagulation: thrombokinase, prothrombin, fibrinogen and calcium

A

Paul Morawitz (1905)

84
Q

Specific component of blood capable of initiating coagulation (tissue factor)

A

Andrew Buchanan(1835/36)

87
Q

RBC appearance

A

Jan Jacbz Swammerdam (1658)