Concepts Of Hemostasis

Question 1

Components of hemostasis

Answer 1

Extravascular
Vascular
Intravascular

Question 2

Factors affecting the extravacular components

Answer 2

Bulk of surrounding tissue
Type of tissue
Tone of tissue

Question 3

The cement that will bind endothelial cells together

Answer 3

Collagen

Question 4

What comprises the intavascular components

Answer 4

Platelets
Coagulation proteins
Fibrinolytic proteins

Question 5

Process of hemostatic funtion

Answer 5

Vessel response
Platelet activation
Coagulation
Fibrinolysis

Question 6

What is the vessel’s response to injury

Answer 6

Vasoconstriction

Question 7

What is the purpose of vasoconstriction in response to vessel damage?

Answer 7

To reduce blood loss

Question 8

What happens in platelet activation

Answer 8

Adhesion
Aggregation
Release reaction
Platelet plug formation

Question 9

When does release reaction happens?

Answer 9

Between platelet adhesion and aggregation

Question 10

What is the purpose of the contents of the granules released by the platelets?

Answer 10

To attract other platelets to go to the site of injury

To cause coagulation reaction

Question 11

What do you call the granules released by the platelets?

Answer 11

Alpha and beta / dense granules

Question 12

Is platelet plug reversible or irreversible?

Answer 12

Reversible

Question 13

Why is platelet plug reversible?

Answer 13

It is unstable and could still be washed off by blood

Question 14

Interacting pathways in coagulation

Answer 14

Intrinsic
Extrinsic
Common

Question 15

Intrinsic pathway is activated by

Answer 15

Collagen

Question 16

Extrinsic pathway is activated by

Answer 16

tissue factor

Question 17

Common pathway forms

Answer 17

Stable/ irreversible clot

Question 18

Fibrin clot is called

Answer 18

Stable/ irreversible clot

Question 19

Activated plasminogen

Answer 19

Plasmin

Question 20

Plasminogen is activated by

Answer 20

Tissue plasminogen activator or TPA

Question 21

What is the purpose of fibrinolysis

Answer 21

Restoration of blood flow

Question 22

What substance causes the dissolution of clot

Answer 22

Plasmin

Question 23

End product of vessel response, platelet activation, coagulation and fibrinolysis

Answer 23

Decrease blood loss
Platelet plug formation
Stable/ irreversible clot
Restoration of blood flow

Question 24

Phases of hemostasis

Answer 24

Primary and secondary

Question 25

What includes the primary hemostasis

Answer 25

Interaction of BV and PLTs leading to decreased blood loss

Question 26

What includes the secondary hemostasis

Answer 26

Interaction between coagulation factors and fibrinolytic proteins leading to the restoration of blood flow

Question 27

Smallest blood vessel

Answer 27

Capillaries

Question 28

BV that reaches the farthest areas of the body

Answer 28

Capillaries

Question 29

Thinnest BV

Answer 29

Capillaries

Question 30

“Back up of capillaries”

Answer 30

Pericytes

Question 31

These are the Larger BV

Answer 31

Arteries and Veins

Question 32

Main function of the capillaries

Answer 32

For metabolic exchange

Question 33

How many cell/s does the capillaries allow to enter

Answer 33

1 cell at a time

Question 34

3 layers of the larger BV

Answer 34

T. Externa/ adventitia T. Interna T. Intima/ interna

Question 35

Outermost layer of the larger BV

Answer 35

T. Externa/ adventitia

Question 36

Components of the T. Adventitia

Answer 36

Adventitial cells or fibroblasts | Collagen

Question 37

Immature cells in the T. Externa tahay would later develop as tissue cells

Answer 37

Adventitial cells or fibroblasts

Question 38

Components of T. Media

Answer 38

Occasional fibroblasts Collagen Smooth muscle Elastic fiber or elastin

Question 39

Arteries have thicker _____ layer than veins

Answer 39

T. Media

Question 40

Components of T. Intima

Answer 40

Collagen | Endothelium same as capillaries

Question 41

What is present in the vein’s T. Interna that is not found in the arteries?

Answer 41

Valves

Question 42

What is the purpose of the valves?

Answer 42

To prevent backflow of blood

Question 43

Adaptive mechanisms of the T. Intima in order to maintain bleed in its liquid state

Answer 43

Coagulation proteins are inactive in form Endothelium is devoid of thrombogenic substances Brisk flow of blood that washes unintended activated proteins 13-hydroxyoctadecadienoic acid/ HODE

Question 44

Barrier between platelets and the emdothelium

Answer 44

13-HODE

Question 45

Synthesised by the endothelium to prevent PLTs from adhering to it in cases of intact vessel

Answer 45

13-HODE