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Hematology2 > Concepts Of Hemostasis > Flashcards

Concepts Of Hemostasis Flashcards

1
Q

Components of hemostasis

A

Extravascular
Vascular
Intravascular

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2
Q

Factors affecting the extravacular components

A

Bulk of surrounding tissue
Type of tissue
Tone of tissue

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3
Q

The cement that will bind endothelial cells together

A

Collagen

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4
Q

What comprises the intavascular components

A

Platelets
Coagulation proteins
Fibrinolytic proteins

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5
Q

Process of hemostatic funtion

A

Vessel response
Platelet activation
Coagulation
Fibrinolysis

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6
Q

What is the vessel’s response to injury

A

Vasoconstriction

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7
Q

What is the purpose of vasoconstriction in response to vessel damage?

A

To reduce blood loss

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8
Q

What happens in platelet activation

A

Adhesion
Aggregation
Release reaction
Platelet plug formation

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9
Q

When does release reaction happens?

A

Between platelet adhesion and aggregation

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10
Q

What is the purpose of the contents of the granules released by the platelets?

A

To attract other platelets to go to the site of injury

To cause coagulation reaction

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11
Q

What do you call the granules released by the platelets?

A

Alpha and beta / dense granules

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12
Q

Is platelet plug reversible or irreversible?

A

Reversible

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13
Q

Why is platelet plug reversible?

A

It is unstable and could still be washed off by blood

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14
Q

Interacting pathways in coagulation

A

Intrinsic
Extrinsic
Common

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15
Q

Intrinsic pathway is activated by

A

Collagen

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16
Q

Extrinsic pathway is activated by

A

tissue factor

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17
Q

Common pathway forms

A

Stable/ irreversible clot

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18
Q

Fibrin clot is called

A

Stable/ irreversible clot

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19
Q

Activated plasminogen

A

Plasmin

20
Q

Plasminogen is activated by

A

Tissue plasminogen activator or TPA

21
Q

What is the purpose of fibrinolysis

A

Restoration of blood flow

22
Q

What substance causes the dissolution of clot

A

Plasmin

23
Q

End product of vessel response, platelet activation, coagulation and fibrinolysis

A

Decrease blood loss
Platelet plug formation
Stable/ irreversible clot
Restoration of blood flow

24
Q

Phases of hemostasis

A

Primary and secondary

25
Q

What includes the primary hemostasis

A

Interaction of BV and PLTs leading to decreased blood loss

26
Q

What includes the secondary hemostasis

A

Interaction between coagulation factors and fibrinolytic proteins leading to the restoration of blood flow

27
Q

Smallest blood vessel

A

Capillaries

28
Q

BV that reaches the farthest areas of the body

A

Capillaries

29
Q

Thinnest BV

A

Capillaries

30
Q

“Back up of capillaries”

A

Pericytes

31
Q

These are the Larger BV

A

Arteries and Veins

32
Q

Main function of the capillaries

A

For metabolic exchange

33
Q

How many cell/s does the capillaries allow to enter

A

1 cell at a time

34
Q

3 layers of the larger BV

A

T. Externa/ adventitia
T. Interna
T. Intima/ interna

35
Q

Outermost layer of the larger BV

A

T. Externa/ adventitia

36
Q

Components of the T. Adventitia

A

Adventitial cells or fibroblasts

Collagen

37
Q

Immature cells in the T. Externa tahay would later develop as tissue cells

A

Adventitial cells or fibroblasts

38
Q

Components of T. Media

A

Occasional fibroblasts
Collagen
Smooth muscle
Elastic fiber or elastin

39
Q

Arteries have thicker _____ layer than veins

A

T. Media

40
Q

Components of T. Intima

A

Collagen

Endothelium same as capillaries

41
Q

What is present in the vein’s T. Interna that is not found in the arteries?

A

Valves

42
Q

What is the purpose of the valves?

A

To prevent backflow of blood

43
Q

Adaptive mechanisms of the T. Intima in order to maintain bleed in its liquid state

A

Coagulation proteins are inactive in form
Endothelium is devoid of thrombogenic substances
Brisk flow of blood that washes unintended activated proteins
13-hydroxyoctadecadienoic acid/ HODE

44
Q

Barrier between platelets and the emdothelium

A

13-HODE

45
Q

Synthesised by the endothelium to prevent PLTs from adhering to it in cases of intact vessel

A

13-HODE

Hematology2 (3 decks)

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