History Flashcards
Beginnings of Laboratory Medicine
The study of disease
Pathology
2 Main divisions of pathology
Anatomic and Clinical Pathology
Study of the body parts
Anatomic Pathology
Study of bodily fluids
Clinical Pathology
Earliest application of pathology
Development of Medicine
Laboratory medicine began with the study of a natural byproduct of all humans that was easily obtained, namely:
Urine
4000 BC
From unearthed papyrus, urine evaluations were performed solely to the members of royalty. Patient care was left to chance, and natures of diseases were based on superstition
300-100 BC
Ancient Hindu physicians poured urine on the ground to observe if ants would be attracted to sweetness of urine
400-301 BC
Hippocrates was the first physician to interpret body functioning based on urine. He determined the value of urine for examination of illness, and utilized human senses in observing symptoms
Father of Medicine
Hippocrates
The first manual laboratory test ever performed
Tasting of urine to confirm its sweetness
101-200 AD
Aelius (Claudius) Glenus “Galen” expanded the ideals of Hippocrates and proposed that urine was only a filtrate of the blood, and that the liquid intake is proportional to output
Early Medieval Ages 500-1300 AD
- Arab and Byzantine monks
- Theophilus Protospatharius
- One of the first actual laboratory technique was performed
- Judaeus Israeli
- Johannes Zaccharias
Authored the first manuscript on urine called “De Urinis”
Theophilus Protospatharius
Believed that diseases are punishment for sinning
Arab and Byzantine Monks
The first actual laboratory test that was done 500 years after Galen
Precipitating protein with heat, causing urine cloudiness
Founder of Origins of Nephrology, and the concept that fluid and sediment from blood seeped into the kidney and to the bladder
Judaeus Israeli
Urine is an exclusive diagnostic tool of legal necessity and physicians are punished if they fail to examine a person’s urine
Jerusalem Code of 1090
Required his patients to collect 24 hours of urine into a clean vessel on an empty stomach
Zan al-Din Sayyed Isma’il ibn Husayn Gorgani
Authored a comprehensive 7-volume manuscript on just urine and detailed how to collect 24-hour urine
Johannes Zacharias
The medical practice of urine testing
Uroscopy
A diagram linking to the color of urine to disease
Urine Wheel
Symbol of the physician in medieval medicine
Urine flask
13th Century (1201-1300)
- Young women involved in medical testing was not considered acceptable
- Modino de Luzzi
- Allessandra Gilliani was employed as a medical/surgical assistant
Using the cadavers of criminals, he “supervised” autopsies and incorporated them into medical training, gaining the title, “Restorer of Anatomy”
Modino de Luzzi
The first female anatomist
Alessandra Gilliani
Late Middle Ages to the Renissance (1301 - 1600 AD)
- Paracelsus
- Leonardo da Vinci studied anatomical techniques in human anatomy sketches
Swiss/German physicist who referred to the balance of minerals and chemical remedies in medicine, also called as the “Father of Toxicology”
Theophrastus von Hohenheim or Paracelsus
Arabian physician who reportedly made the first postmortem dissections
Avenzoar