History

Question 1

Grube

Answer 1

Discovered radiation therapy in x rays

Question 2

Peyton Raus

Answer 2

Discovered Raus Sarcoma virus, came up with viral carcinogenesis

Question 3

What are some viral causes of cancer?

Answer 3

EPV, Hep B/C, HPV

Question 4

Bruce Aines

Answer 4

Discovered mutagens work as carcinogens in 1967

Question 5

Michael Bishop

Answer 5

Studied RSV, found gene that causes carcinogenesis (SRC)
Virus picks up mutant, injects into host cell

Question 6

Robert Virchow

Answer 6

Created cell theory “Omnis cellua e cellua”

Question 7

Bernard Fischer

Answer 7

Reduted radical mastectomy, tested theory with randomized clinical trial

Question 8

William Halsted

Answer 8

Created radical mastectomy
Cut more, cure more

Question 9

VAMP

Answer 9

Combination chemo, 4 drugs, 60s, failure

Question 10

Frei and Freireich

Answer 10

Worked at the NCI, looked for anti-cancer compounds

Question 11

How was chemical carcinogenesis discovered?

Answer 11

Chimney sweeps got scrotal cancer (Pott)

Question 12

Mary Lasker

Answer 12

Socialite, fundraised with Farber

Question 13

Vesalius

Answer 13

Mapped human bodies in 1530s through autopsies, discovered black bile didn’t exist

Question 14

Robert Weinberg

Answer 14

Discoveres RAS (oncogene) in the late 70s

Question 15

Sydney Farber

Answer 15

Father of chemotherapy, used aminopterin to treat leukemia

Question 16

4 humors

Answer 16

Excess of black bile (melancholia) caused cancer