Histoplasma capsulatum

Question 0

H. Capsulatum

Answer 0

Grows in soil and material contaminated with bar it bird droppings …. Becomes airborne when contaminated soil is disturbed

Question 1

Histoplasmosis

Answer 1

Histoplasma Capsilatum
Inhalator of airborne spores
Primarily affects lungs
Desalinated histoplasmosis

Question 2

Histoplasmosis

Answer 2

S/S resemble TB 
3-17 days after exposure average 10 dads 
Acute primary 
Chronic cavitary 
Disseminated

Question 3

Acute histoplasmosis

Answer 3

Pulmonary lesions
Nodules contains aggregated of macrophages with engulfed microorganisms
Mild flu like syndrome

Question 4

Chronic histoplasmosis

Answer 4

Cavitary lesions upper love
Secondary form of TB
Productive cough fever night Sears weight loss

Question 5

Histoplasmosis disseminated

Answer 5

Acute and fulminating (suddenly and severely ) very old very young immunocomprimised
Macrophages remove the fungus from blood steam but unable to destroy them FATAL if untreated

Question 6

Histoplasmosis continued

S/s

Answer 6

High fever 
Generalized lymph node enlargement 
Hepatsplenomegaly 
Muscle wasting
Anemia 
Leukopenia/ thrombocytopenia 
Hoarseness 
V/D 
Abd pain 
Meningitis 
lesions resemble  squamous cell carcinoma

Question 7

Diagnosis

Answer 7

Skin test
Tissue section
Sputum culture
Serologic tests