Histopathology of Neoplasia

Question 1

Tumor parenchyma and

Reactive stroma

Answer 1

Components of a tumor.
parenchyma = neoplastic cells within the tumor mass

stroma = non-neoplastic connective tissue, blood vessels, immune cells, etc. w/in tumor mass

Question 2

pleomorphism

Answer 2

variation in size and shape (MORE pleomorphic = more likely to be malignant)

Question 3

anaplasia

Answer 3

lack of differentiation (LESS differentiated the cells are the more likely they are to be malignant)

Question 4

-oma

Answer 4

benign neoplasms

Question 5

-CARCINoma

Answer 5

malignant neoplasm from EPITHELIAL

Question 6

-SARComa

Answer 6

malignant neoplasm from MESENCHYMAL

Question 7

teratoma

Answer 7

neoplasm of germ cells with derivatives of germ layers

Question 8

7 common Histologic features of Benign neoplasms

Answer 8

1. smooth margins
2. circumscribed
3. encapsulated
4. uniform
5. good differentiation
6. low mitotic activity
7. lack of hemorrhage and necrosis

Question 9

5 common Histologic features of Malignant neoplasms

Answer 9

1. infiltrating margins (fibrotic response called desmoplasia)
2. variegated composition (due to necrosis and hemorrhaging)
3. Lack of resemblance to cell/tissue of origin (variable differentiation)
4. Cellular atypia (pleomorphism anaplasia)
5. Mitotic activity
   (atypical mitosis)*

Question 10

Dysplasia

Answer 10

disordered growth of neoplastic EPITHELIAL cells, confined by the basement membrane (loss of uniformity and polarity)

Question 11

Intraepithelial Neoplasia

Answer 11

synonym for dysplasia

disordered growth of neoplastic EPITHELIAL cells, confined by the basement membrane (loss of uniformity and polarity)

Question 12

Carcinoma in situ

Answer 12

highest grade of dysplasia with all cellular features of carcinoma still confined by basement membrane