Ciliopathies

Question 1

Motile Cilia’s Purpose

Answer 1

Beat it!

Question 2

5 common places where is Motile Cilia found?

Answer 2

1. Brain
2. Embryonic Node
3. Respiratory Tract
4. Sperm
5. Female Reproductive Tract

Question 3

Non-Motile/ Primary Cilia’s purpose is to:

Answer 3

SIGNAL

Question 4

Where are Primary Cilia found?

Answer 4

“almost every vertebrate cell” has primary cilia to act like an antenna and transduce info from external environment

Question 5

Anterorgrade Intraflagellar Transport (IFT)

Answer 5

From base to the tip of cilia

cilia with a MICROTUBULE “BASED” core that extends out from the plasma membrane and
acts like a train to move protein OUT:
–>Kinesin and IFT COMPLEX B

Question 6

Axoneme

Answer 6

Microtubule-based core of cilia

Question 7

Retrograde Intraflagellar Transport

Answer 7

From the tip to the base of the cilium

cilia with a MICROTUBULE “BASED” core that acts like a train to return protein IN:
–> requires Dynein motor and IFT COMPLEX A

Question 8

What are Ependymal Cilia? What disease are they associated with?

Answer 8

Ependymal Cilia are the cilia that move CSF through brain and spinal cord. Pathologic E. cilia cause HYDROCEPHALUS

Question 9

Basal Body?

Answer 9

AKA Centriole. This is the base on the apical side of a cell that cilium extend from.