Histopathology Flashcards
- IVDU drug user is found to have tricuspid valve dysfunction
A - Atheroma
B - MI
C – LV Heart Failure
D – Congestive Heart Failure
E – Dilated Cardiomyopathy
F – Hypertrophic Cardiomyopathy
G – Restrictive Cardiomyopathy
H – Strep Pyogenes
I – Staph Aureus
J – Strep Viridans
I - Staph Aureus
- Diabetic 60 year old man attends A&E following a collapse where he felt sweaty and turned grey
A - Atheroma
B - MI
C – LV Heart Failure
D – Congestive Heart Failure
E – Dilated Cardiomyopathy
F – Hypertrophic Cardiomyopathy
G – Restrictive Cardiomyopathy
H – Strep Pyogenes
I – Staph Aureus
J – Strep Viridans
B - MI
- 33 year old woman is found to have systolic dysfunction post-partum. Which cardiomyopathy does she have?
A - Atheroma
B - MI
C – LV Heart Failure
D – Congestive Heart Failure
E – Dilated Cardiomyopathy
F – Hypertrophic Cardiomyopathy
G – Restrictive Cardiomyopathy
H – Strep Pyogenes
I – Staph Aureus
J – Strep Viridans
E - Dilated cardiomyopathy
- 6 year old boy with joint pain, rash and new onset “tic” attends his GP
A - Atheroma
B - MI
C – LV Heart Failure
D – Congestive Heart Failure
E – Dilated Cardiomyopathy
F – Hypertrophic Cardiomyopathy
G – Restrictive Cardiomyopathy
H – Strep Pyogenes
I – Staph Aureus
J – Strep Viridans
H - Strep pyogenes
- 70 year old woman is taken to autopsy. The left ventricle is hypertrophied with myocardial fibrosis and she is found to have a nutmeg liver.
A - Atheroma
B - MI
C – LV Heart Failure
D – Congestive Heart Failure
E – Dilated Cardiomyopathy
F – Hypertrophic Cardiomyopathy
G – Restrictive Cardiomyopathy
H – Strep Pyogenes
I – Staph Aureus
J – Strep Viridans
C - LV Heart Failure
- 50 year old farmer presents with a chronic cough, finger clubbing and severe weight loss
A - Chronic Bronchitis
B - Bronchiectasis
C – Asthma
D – Emphysema
E – Bronchiolitis
F – Extrinsic Allergic Alveolitis
G – Idiopathic Pulmonary Fibrosis
H – Pneumoconiosis
I – Pneumonia
F - Extrinsic Allergic Alveolitis
- 60 year old man presents with increasing exertional dyspnoea and is found to have honeycomb changes in his lungs.
A - Chronic Bronchitis
B - Bronchiectasis
C – Asthma
D – Emphysema
E – Bronchiolitis
F – Extrinsic Allergic Alveolitis
G – Idiopathic Pulmonary Fibrosis
H – Pneumoconiosis
I – Pneumonia
G - Idiopathic Pulmonary Fibrosis
- This disease shows Curschmann spirals, eosinophils and Charcot Leyden crystals on histology
A - Chronic Bronchitis
B - Bronchiectasis
C – Asthma
D – Emphysema
E – Bronchiolitis
F – Extrinsic Allergic Alveolitis
G – Idiopathic Pulmonary Fibrosis
H – Pneumoconiosis
I – Pneumonia
C - Asthma
- A bright pink gentleman presents to his hepatology clinic very out of breath and trying to puff through his lips. CXR shows panacinar emphysema
A - Chronic Bronchitis
B - Bronchiectasis
C – Asthma
D – Emphysema
E – Bronchiolitis
F – Extrinsic Allergic Alveolitis
G – Idiopathic Pulmonary Fibrosis
H – Pneumoconiosis
I – Pneumonia
D - Emphysema? I think?
- 70 year old builder is found to have increased collagen deposits in his lung biopsy and is told that he is at risk of mesothelioma
A - Chronic Bronchitis
B - Bronchiectasis
C – Asthma
D – Emphysema
E – Bronchiolitis
F – Extrinsic Allergic Alveolitis
G – Idiopathic Pulmonary Fibrosis
H – Pneumoconiosis
I – Pneumonia
H - Pneumoconiosis
- 60 year old obese male smoker has noticed red stretch marks across his stomach recently. High dose dexamethasone test is negative and he is sent for further investigations. Lung biopsy shows oat cells and the diagnosis is made.
A – Squamous Cell Carcinoma
B - Adenocarcinoma
C – Small Cell Carcinoma
D – Large Cell Carcinoma
E – Mesothelioma
F – Renal Cell Carcinoma
G – Pulmonary Embolism
C - Small cell carcinoma
- Lung biopsy of a female non-smoker shows a mass of glandular cells containing mucin vacuoles. She is treated with imatinib.
A – Squamous Cell Carcinoma
B - Adenocarcinoma
C – Small Cell Carcinoma
D – Large Cell Carcinoma
E – Mesothelioma
F – Renal Cell Carcinoma
G – Pulmonary Embolism
B - Adenocarcinoma
- Histology of a male smoker’s lung tumour shows keratinisation and intercellular prickles. Cells are found to have a high rate of p53/c-myc mutations
A – Squamous Cell Carcinoma
B - Adenocarcinoma
C – Small Cell Carcinoma
D – Large Cell Carcinoma
E – Mesothelioma
F – Renal Cell Carcinoma
G – Pulmonary Embolism
A - Squamous cell carcinoma
- Man presents with facial flushing and a chronic cough. Biopsy shows a poorly differentiated epithelial tumour. Cells are large with prominent nucleoli.
A – Squamous Cell Carcinoma
B - Adenocarcinoma
C – Small Cell Carcinoma
D – Large Cell Carcinoma
E – Mesothelioma
F – Renal Cell Carcinoma
G – Pulmonary Embolism
D - Large cell carcinoma?
- Patient presents following breast cancer surgery with a peripheral wedge lung infarction
A – Squamous Cell Carcinoma
B - Adenocarcinoma
C – Small Cell Carcinoma
D – Large Cell Carcinoma
E – Mesothelioma
F – Renal Cell Carcinoma
G – Pulmonary Embolism
G - Pulmonary Embolism
- Alcoholic presents with progressive dysphagia, anorexia and weight loss. On examination she has lymphadenopathy
A – Barrett’s Oesophagus B - GORD C – Oesophageal Cancer D – Oesophageal Varices E – Gastric Ulcer F – Gastritis G – Duodenal ulcer H – Gastric Lymphoma I – Coeliac Disease
C - Oesophageal cancer?
- Lady with history of Barrett’s oesophagus presents with odynophagia and weight loss
A – Barret’s Oesophagus B - GORD C – Oesophageal Cancer D – Oesophageal Varices E – Gastric Ulcer F – Gastritis G – Duodenal ulcer H – Gastric Lymphoma I – Coeliac Disease
C - Oesophageal cancer?
- Metaplasia of squamous mucosa to columnar epithelium
A – Barrett’s Oesophagus B - GORD C – Oesophageal Cancer D – Oesophageal Varices E – Gastric Ulcer F – Gastritis G – Duodenal ulcer H – Gastric Lymphoma I – Coeliac Disease
A - Barett’s Oesophagus
4. Alcoholic presents in shock having vomited “just blood” A – Barrett’s Oesophagus B - GORD C – Oesophageal Cancer D – Oesophageal Varices E – Gastric Ulcer F – Gastritis G – Duodenal ulcer H – Gastric Lymphoma I – Coeliac Disease
D - Oesophageal varices
5.20 year old woman with rheumatoid arthritis presents with epigastric pain, worse at night.
A – Barret’s Oesophagus B - GORD C – Oesophageal Cancer D – Oesophageal Varices E – Gastric Ulcer F – Gastritis G – Duodenal ulcer H – Gastric Lymphoma I – Coeliac Disease
G - Duodenal ulcer
- Histology shows backwash iletis, pseudopolyps and superficial inflammation
A – Hirschprung’s disease B – Crohn’s C – UC D – C.diff E – Adenomatous polyp F – Hamartomatous polyp G – Hyperplastic polyp
C - UC
2. Histology shows non-caeseating granulomas and rosethorn ulcers A – Hirschprung’s disease B – Crohn’s C – UC D – C.diff E – Adenomatous polyp F – Hamartomatous polyp G – Hyperplastic polyp
B - Crohns
3. Histology shows absence of ganglia in mesenteric plexus A – Hirschprung’s disease B – Crohn’s C – UC D – C.diff E – Adenomatous polyp F – Hamartomatous polyp G – Hyperplastic polyp
A - Hirschprungs
- Histology shows patchy transmural inflammation in the terminal ileum and caecum
A – Hirschprung’s disease B – Crohn’s C – UC D – C.diff E – Adenomatous polyp F – Hamartomatous polyp G – Hyperplastic polyp
B - Crohns
- Histology shows tubular polyps and a mutation in the APC gene
A – Hirschprung’s disease B – Crohn’s C – UC D – C.diff E – Adenomatous polyp F – Hamartomatous polyp G – Hyperplastic polyp
E - Adenomatous polyp
- Woman with colorectal cancer told she has a 95% chance of survival. What Duke’s stage is she?
A – Peutz-Jeghers Syndrome B – Lynch Syndrome C – FAP D – Gardner’s E – Duke’s stage A F – Duke’s stage C1 G – Duke’s stage C2
E - Duke stage A
- Cancer extends to muscularis propria with LN mets. What Duke’s stage?
A – Peutz-Jeghers Syndrome B – Lynch Syndrome C – FAP D – Gardner’s E – Duke’s stage A F – Duke’s stage C1 G – Duke’s stage C2 `
F - Duke stage C1
- 5 year old with hamartomatous polyps in his colon and mucocutaneous hyperpigmentation. Found to have freckles around mouth.
A – Peutz-Jeghers Syndrome B – Lynch Syndrome C – FAP D – Gardner’s E – Duke’s stage A F – Duke’s stage C1 G – Duke’s stage C2
A - Peutz-Jeghers syndrome
4. Associated with colon cancer, osteomas and dental caries A – Peutz-Jeghers Syndrome B – Lynch Syndrome C – FAP D – Gardner’s E – Duke’s stage A F – Duke’s stage C1 G – Duke’s stage C2
D - Gardner’s - Familial adenomatous polyposis + osteomas, dental caries, epidermoid cysts + desmoid tumours
- Caused by an AD mutation in DNA mismatch repair genes
A – Peutz-Jeghers Syndrome B – Lynch Syndrome C – FAP D – Gardner’s E – Duke’s stage A F – Duke’s stage C1 G – Duke’s stage C2
B - Lynch syndrome - Hereditary non-polyposis colorectal Ca
- Associated with Zollinger-Ellison syndrome
A – Ductal adenocarcinoma of the pancreas B - Insulinoma C – Gastrinoma D – Glucagonoma E – MEN1 F – Pancreas Divisum G – Lipoprotein lipase deficiency
C - Gastrinoma
- Tumour in tail of pancreas. Patient may present with hypoglycaemia.
A – Ductal adenocarcinoma of the pancreas B - Insulinoma C – Gastrinoma D – Glucagonoma E – MEN1 F – Pancreas Divisum G – Lipoprotein lipase deficiency
B - Insulinoma
- 60 year old man with epigastric pain and cachexia. Bloods show raised bilirubin, calcium and ca19.9
A – Ductal adenocarcinoma of the pancreas B - Insulinoma C – Gastrinoma D – Glucagonoma E – MEN1 F – Pancreas Divisum G – Lipoprotein lipase deficiency
A - ductal adenocarcinoma of the pancreas? I think? Or MEN1?
- 5 year old boy with recurrent acute pancreatitis found to have “milky” plasma and chylomicrons after a period of fasting
A – Ductal adenocarcinoma of the pancreas B - Insulinoma C – Gastrinoma D – Glucagonoma E – MEN1 F – Pancreas Divisum G – Lipoprotein lipase deficiency
G - Lipoprotein lipase deficiency
- Congenital risk factor for pancreatitis caused by failure of dorsal and ventral buds to fuse
A – Ductal adenocarcinoma of the pancreas B - Insulinoma C – Gastrinoma D – Glucagonoma E – MEN1 F – Pancreas Divisum G – Lipoprotein lipase deficiency
F - Pancreas divisum
- Jaundiced patient presents with seizures and ataxia. Liver biopsy is rhodanine stain positive. Mallory bodies are found on microscopy
A – Hepatic adenoma B - Haemangioma C – Viral cirrhosis D – Alcoholic cirrhosis E – Haemochromatosis F – Wilson’s disease G – Alpha-1-antitrypsin H – Primary sclerosing cholangitis
F - Wilsons disease
- Jaundiced patient presents with epigastric pain. Bloods show raised ALP and p-ANCA. ERCP shows beading of the bile ducts.
A – Hepatic adenoma B - Haemangioma C – Viral cirrhosis D – Alcoholic cirrhosis E – Haemochromatosis F – Wilson’s disease G – Alpha-1-antitrypsin H – Primary sclerosing cholangitis
H - Primary sclerosing cholangitis
- Autosomal recessive condition caused by a mutated HFE gene
A – Hepatic adenoma B - Haemangioma C – Viral cirrhosis D – Alcoholic cirrhosis E – Haemochromatosis F – Wilson’s disease G – Alpha-1-antitrypsin H – Primary sclerosing cholangitis
E - Haemochromatosis
- Autopsy of a liver shows large nodules and bands of fibrous tissue
A – Hepatic adenoma B - Haemangioma C – Viral cirrhosis D – Alcoholic cirrhosis E – Haemochromatosis F – Wilson’s disease G – Alpha-1-antitrypsin H – Primary sclerosing cholangitis
? A1 antitrypsin? literally not sure
- 24 year old female presents with intraperitoneal bleeding and abdominal pain. She is on the OCP. CT shows a hepatic mass.
A – Hepatic adenoma B - Haemangioma C – Viral cirrhosis D – Alcoholic cirrhosis E – Haemochromatosis F – Wilson’s disease G – Alpha-1-antitrypsin H – Primary sclerosing cholangitis
A - Hepatic adenoma
- Painless haematuria in a clothes merchant.
A - Cystitis B – Transitional cell carcinoma C – Squamous cell carcinoma D – BPH E – Prostate cancer F – Prostatitis G – Teratoma H – Seminoma I – Renal cell carcinoma
B - Transitional cell carcinoma
- Egyptian male presents with haematuria. He would like to get it cleared up before he goes back home for a canoeing contest
A - Cystitis B – Transitional cell carcinoma C – Squamous cell carcinoma D – BPH E – Prostate cancer F – Prostatitis G – Teratoma H – Seminoma I – Renal cell carcinoma
C - squamous cell carcinoma?
- Man presents with dysuria which resolves after 3 days of treatment
A - Cystitis B – Transitional cell carcinoma C – Squamous cell carcinoma D – BPH E – Prostate cancer F – Prostatitis G – Teratoma H – Seminoma I – Renal cell carcinoma
A - cystitis
- Man presents with dysuria, groin pain and a high temperature
A - Cystitis B – Transitional cell carcinoma C – Squamous cell carcinoma D – BPH E – Prostate cancer F – Prostatitis G – Teratoma H – Seminoma I – Renal cell carcinoma
F - Prostatitis?
- Young boy with an enlarged testicle as high AFP, HCG and LDH on bloods
A - Cystitis B – Transitional cell carcinoma C – Squamous cell carcinoma D – BPH E – Prostate cancer F – Prostatitis G – Teratoma H – Seminoma I – Renal cell carcinoma
G - Teratoma
