Histone variants Flashcards

1
Q

H3.3?

A

A variant of H3 with only 4aa difference. However, this 4aa difference is evolutionarily conserved. Present in both active genes and constitutive heterochromatin

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2
Q

CenH3?

A

aka CENP-A. Present specifically in centrosomal chromatin.

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3
Q

What are two H3 veriants

A

H3.3 and CenH3

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4
Q

(gamma)H2AX

A

recruited at DSBs. gamma means phosphorylated

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5
Q

When are new H2AX recruited to chromatin?

A

gamma-H2AX can be
added at any time during the cell cycle as DSB can happen at anytime not just S phase

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6
Q

H2A.Z?

A

active promoters. H2A.Z wraps DNA more tightly, which will have
consequences on how gene transcription will proceed. In plants for example, its loading onto chromatin is somewhat
temperature-dependent.

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7
Q

mH2A?

A

macroH2A. Only present in vertebrates. It has 200aa more than the regular H2A, and is
enriched on the inactive X chromosome. (m = mommy)

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8
Q

H2A.B?

A

It is deposited at sites where
active transcription, splicing, etc are happening, but only in testis cells. (B = balls)

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