Ageing

Question 1

epigenetic drift

Answer 1

the divergence in DNA methylation or more generally
the epigenome as the cells or body age

Question 2

a decrease in histone acetylation in H4K16 would indicate what

Answer 2

getting younger haha

Question 3

Sir2

Answer 3

H4K16 DAC

Question 4

Hutchinson-Guilford Progeria Syndrome

Answer 4

dramatic disease characterized by premature ageing
caused by mutation in LaminA (mostly), componenti in the nuclear lamina => deformed nucleus

Question 5

What is a relation between LaminA expression and H4K16Ac levels.

Answer 5

If LaminA is mutated, heterochromatin that is generally localized there could migrater and become acetylated. As activating certain genes through H4K16Ac has been related to ageing this is one of the main reasons of people with progeria to age so quickly.

Question 6

What happens to H3K9me levels globally in HGPS?

Answer 6

Loss of H3K9me3!

Loss of contacts with the lamina will lead to a more permissive environment. The
chromatin will lose H3K9me and have more H4K16ac -> accelerated ageing.
HGPS patients show very premature ageing because the chromatin in their nuclei
detaches from the nuclear lamina, leading to global loss of H3K9me3 and gene
reactivation.