Histology of Adipose Tissue Flashcards
What are the main functions of adipose tissue?
Adipose tissue is a type of specialized connective tissue with several functions:
* Stores fat for energy use
* Provides insulation from the cold
* Provides padding around organs
* Brown adipose can generate heat for newborns
* Releases hormones like leptin and estrogen (synthetic organ)
What cell types make up adipose tissue?
Adipose tissue is mainly adipocytes but the tissue also contains:
* Fibroblasts
* Vascular endothelial cells
* Macrophages
Each adipocyte is surrounded by a thick, specialized ECM called the _
Each adipocyte is surrounded by a thick, specialized ECM called the basal lamina
The basal lamina surrounding the adipocytes contains type _ collagen
The basal lamina surrounding the adipocytes contains type IV
* The basal lamina supports adipocytes, which are otherwise susceptible to injury because of the scanty cytoplasm
Differentiate between white adipose tissue and brown adipose tissue
White adipose tissue stores fat for energy needs
Brown adipose tissue generates body heat by metabolizing fat
Both white and brown adipose tissue stores fat in organelles called _
Both white and brown adipose tissue stores fat in organelles called lipid droplets
* Each white adipocyte has one lipid droplet
* Brown adipocytes have many lipid droplets
What do white adipocytes look like?
Each white adipocyte contains a central lipid droplet containing fat; this pushes the cytoplasm and nucleus to the periphery of the cell
* Cell can increase 20-fold in diameter
* Stored fat is mainly in form of triglycerides and cholesterol esters
What do brown adipocytes look like?
Brown adipocytes are smaller than white, they have multiple smaller lipid droplets per cell
* More abundant cytoplasm
* Nucleus is in the center
* Brown color comes from high quantity of mitochondria
White adipocytes have a remarkable ability to expand and store energy in the form of TG in the adipose tissue and liver; however, white fat is associated with _ and _
White adipocytes have a remarkable ability to expand and store energy in the form of TG in the adipose tissue and liver; however, white fat is associated with heart attacks and strokes
The main fat storage hormone is _
The main fat storage hormone is insulin
* It gets released from the islet cells of the pancreas
* Then binds to white adipose cell receptors
* And it inactivates lipase to promote fat storage
If higher fat mass leads to higher leptin, then why don’t we lose our appetite when we gain weight?
Leptin resistance at the receptor level
Explain the involvement of cytokines in obesity
Adipocytes contribute to a state of inflammation by secreting cytokines and inflammatory modulators like plasminogen, activator inhibitor 1, monocyte chemoattractant protein 1, TNFa, IL-6, and IL-8
* Macrophages in the adipose tissue also releases pro-inflammatory cytokines
Leptin binds to _ in the brain and acts to _
Leptin binds to the hypothalamus in the brain and acts to reduce hunger and stimulate satiety
Fat mobilization is caused by the following hormones:
Fat mobilization is caused by the following hormones: epinephrine, norepinephrine, glucagon, growth hormone, cortisol
* These activate lipase to cause breakdown from TG –> fatty acids + glycerol
* Fatty acids then get used by muscle and cardiac tissue for energy
* Glycerol is taken up by the liver to make new glucose
List some common sites of white fat deposition
Subcutaneous fat: located beneath the skin
Visceral fat: located around visceral organs (intra-abdominal)
Breast fat: in breast tissue
Marrow fat: in bone marrow
Ectopic fat: abnormal deposition in the muscles, heart, liver, pancreas