histology Flashcards
bone
highly specialized calcified CT rich in blood supply
functions of bone
(5)
skeleton
attachment media
protects vital organs
reservoir for minerals
formation of blood cells
composition of bone
(2)
inorganic (67%)
organic & water (33%)
inorganic substances (67%)
(2)
- mostly calcium and phosphate
- causes hardness of bone
organic substances (33%)
(2)
- 28% collagen fibers
- 5% ground substances
5% ground substances components
(3)
glycosaminglycan (GAG)
glycoprotein
phosphoprotein
bone structure
(2)
periosteum & endosteum
periosteum def
(hint: 2 layers) (2)
- lines the outer surface of compact bone
- 2 layers (outer fibrous & inner cellular)
sharpeys fibers are collagenous fibers from…
outer layer of periosteum which insert into bone to firmly attach periosteum to bone
endosteum def
(hint: lines what) (3)
- lines inner surface of compact bone
- lines haversian canals
- surrounds surface of spongy bone
functions of peri & endo
(2)
- contain blood vessels for nutrition
- source of osteoblasts
bone cells :
(4)
- osteoprogenitor (osteogenic)
- osteoblasts
- osteoclasts
- osteocytes
osteogenic
(2)
- mitotically active stem cells
- differentiate into osteoblasts
osteoblasts
(3)
- bone forming cells
- secrete unmineralized bone matrix called osteoid
- actively mitotic
osteoid
(2)
- made of collagen & calcium binding proteins
- later hardens into bone
osteocytes
(4)
- in lacunae & dont divide
- maintain matrix, & act as stress sensors
- respond to mechanical stimuli
- communicate info to osteoblasts & osteoclasts
bone lining cells
(4)
- flat cells on bone surface
- help maintain matrix
- peri = external
- endo = internal
osteoclasts
(4)
- from hematpoietic stem cells that become macrophages
- giant multinucleated resorbing cells
- located in howships lacunae
- ruffled borders for enzyme degradation
types of bones
(3)
non- lamellar
lamellar
bundle bone
non-lamellar bone
(4)
- found in fetal life, extraction socket & fratures
- lots of osteocytes
- irregular & less mineralized
- temporary
lamellar bone types
(2)
- compact
- spongy
compact lamellar bone
(hint: 3 types) (4)
- very dense, no marrow space
- has 3 types:
- circumferential
- haversian
- interstitial
haversian lamellae
(4)
- arranged in 4-20 lamellae rings (haversian system)
- has b.v, nerves, C.T. & lined by endosteum
- connected to each other by volkmans cannals
- connected to osteocytes & haversian canals by canaliculi
circumferential lamellae
(2) (forms what…)
- adjacent to periosteum & endosteum
- forms external & internal lamination of cortical bone