Histo Ddx Flashcards
1
Q
Acanthosis and balloon cells in upper layer of epithelium
A
- Hairy leukoplakia
- Morsicatio
- Leukoedema
- Linea alba
- Betel chewer’s mucosa
- Uremic stomatitis
- White sponge nevus
2
Q
Acantholytic lesions:
A
- Pemphigus
- Hailey-‐Hailey (chronic benign familial pemphigus – rare in mouth)
- Herpes
- Grover’s (transient acantholytic dermatosis – exclusively suprabasal split)
- Darier’s
- Warty dyskeratoma
- Varicella-‐zoster
- Squamous cell carcinoma
- Pyostomatitis vegetans (has eos)
3
Q
Amorphous material in connective tissue
A
- Amyloidosis (amyloid)
- Systemic sclerosis (collagen)
- Plasminogen deficiency (fibrin)
- Lipid proteinosis (basement membrane origin)
4
Q
Clear cell neoplasms of the jaws
A
- Clear cell odontogenic ca.
- Ameloblastoma (if there’s peripheral palisading)
- Mucoep, central (if there’s mucin in a mucicarmine stain)
- CEOT, clear cell variant (if there’s amyloid)
- Met (like Renal, breast, or clear cell melanoma)
- Melanoma (HMB-‐45 +)
5
Q
Clear cell salivary gland tumors:
A
- Hyalinizing clear cell ca. (dense hyalinized stroma)
- Myoepithelioma (extremely rare, benign features)
- Myoepithelial ca. (no ductal elements)
- Acinic cell ca. (typical areas are normally present)
- Clear cell adenoca.
- Epithelial-‐myoepithelial carcinoma (biphasic)
- Muco ep. (epidermoid cells present, typical areas normally present)
- Oncocytoma (usually has typical oncocytic cells)
- Sebaceous adenoma (clear cells have foamy cytoplasm)
- Sebaceous adenoca (clear cells have foamy cytoplasm)
- Metastatic renal cell carcinoma (very vascular, CD10+)
6
Q
Comedonecrosis:
A
- SNUC
- Basaloid SCC
- NPC
- Salivary duct ca.
- Met (breast, ductal ca)
7
Q
Cystic lesions of the salivary glands:
A
- Acinic cell
- BLEL/Sjögren’s
- Polycystic disease of the parotid/ HIV-‐related parotid cysts
- Papillary Cystadenoma/cystadenocarcinoma
- Warthin’s
- Salivary duct cyst
- Sclerosing polycystic adenosis
- Muco Ep
- Lymphoepithelial cyst/ Branchial cleft cyst
- Sebaceous lymphadenoma
- Dermoid/epidermoid cyst
8
Q
Dyskeratotic cells:
A
- Warty dyskeratoma
- Hereditary benign intraepithelial dyskeratosis
- Darier disease
- Hereditary mucoepithelial dysplasia
- Pachyonychia congenital
9
Q
Eosinophils
A
- Allergic fungal sinusitis
- Langerhan’s cell histiocytosis
- Angiolymphoid hyperplasia with eosinophilia
- Kimura’s disease
- Hodgkin’s lymphoma
- Peripheral T cell lymphoma (also shows fat invasion – panniculitis pattern)
- TUGSE
- Pyostomatitis Vegetans (microabcesses in epithelium)
10
Q
Fibrous tumors of the jaws:
A
- Odontogenic fibroma (w/o odontogenic epithelium, not the WHO type)
- Desmoplastic fibroma
- Fibromyxoma
- Hyperplastic dental follicle (if related to a tooth)
11
Q
Giant cell lesions of the oral cavity and jaws:
A
- Sarcoid
- Crohn’s disease
- Fungal infection
- Bacterial infection (TB/ leprosy)
- CGCG/ PGCG
- Brown tumor (hyperparathyroidism or renal osteodystrophy)
- Cherubism
- ABC
- Central odontogenic fibroma
- Osteosarcoma
- Foreign body reaction
- Juvenile xanthogranuloma
- Herpes
12
Q
Granular cell lesions:
A
- Granular cell tumor
- Congenital epulis
- Granular cell odontogenic tumor
- Granular cell ameloblastoma
13
Q
Granulomatous inflammation:
Caseating/ necrotizing-‐
A
- Tuberculosis
- Cat scratch
- Syphilis
- Foreign body
- Blastomycosis
- Wegener’s
14
Q
Granulomatous inflammation:
Non-‐necrotizing-‐
A
- Fungal (histoplasmosis, paracoccidioides, coccidioides imitans-‐San Joaquin Valley Fever)
- Leprosy
- Crohn’s
- Sarcoid
- Wegener’s
- Orofacial granulomatosis
- Foreign body
15
Q
Intraepithelial Abscess:
A
- Pyostomatitis vegetans (eos)
- Inverted papilloma
- Blastomycosis
- Psoriasis/ BMG/ EM (also, the lesions of Reiter’s)
- Papillary SCC/ VC
- Candidiasis
- Schneiderian oncocytic pap.
