High-Yield Concepts in Inflammatory Bowel Disease (Gastrointestinal Diseases)

Question 1

Ulcerative Colitiis (UC)

Answer 1

Mucosal disease that usually involves the rectum & extends proximally to involve all or part of the of the colon

Question 2

Crohn’s Disease (CD)

Answer 2

Can affect any part of the GIT from mouth to anus, but rectum is often spared (in contrast to UC)

Question 3

Toxic Megacolon

Answer 3

Transverse or right colon with diameter of >6 cm and loss of haustrations in severe attacks of UC

Question 4

pANCA Positivity (Perinuclear Anti-neutrophil Cytoplasmic Antibodies)

Answer 4

UC&raquo_space; CD

Question 5

ASCA Positivity (Anti-Saccharomyces cerevisiae Antibodiess)

Answer 5

CD&raquo_space; UC

Question 6

Markers of Intestinal Inflammation

Answer 6

Fecal lactoferrin and calprotectin (leukocyte-derived proteins)

Question 7

Appendectomy

Answer 7

Protective against UC, increased risk of DC

Question 8

Earliest lesions in CD

Answer 8

Aphthoid ulcerations and focal crypt abscesses

Question 9

Pathognomonic feature of CD

Answer 9

Granulomas

Question 10

Most common site of inflammation in CD

Answer 10

Terminal ileum

Question 11

Earliest radiologic change of UC seen on barium enema

Answer 11

Fine mucosal granularity

Question 12

Most dangerous local complication of UC

Answer 12

Perforation

Question 13

Most common ocular complications of IBD

Answer 13

Conjunctivitis, anterior uveitis/iritis, and episcleritis

Question 14

Most common genitourinary complications of IBD

Answer 14

Calculi, ureteral obstruction, and fistulas

Question 15

Mainstay of therapy for mild to moderate UC and Crohn’s Colitis

Answer 15

Sulfasalazine and other 5-ASA agents

Question 16

Treatment of moderate to severe IBD

Answer 16

Glucocorticoids (no role as maintenance therapy)

Question 17

First biologic therapy approved for CD

Answer 17

Infliximab (TNF-alpha antibody)

Question 18

Operation of choice for UC

Answer 18

Ileal Pouch Anal Anastomosis (IPAA)

Question 19

Most frequent late complication of IPAA

Answer 19

Pouchitis