High Yield 2 Flashcards
What antiarrhythmics
- Prolongs action potential and refractory period
- shortens action potential and repolarization
- Class Ia (procainamide, quindine), Class III (amiodarone, sotalol)
- Class Ib (lidocaine)
intermittent pain and tingling sensation in arm, occasional swelling of arm on abduction, loss of radial pulse when head turned to affected side
DX and TX?
thoracic outlet syndrome- idiopathic compression of brachial plexus, subclavian artery or vein
DX: + Adson test- loss of radial pulse when turning head to affected side
What are possible complications of the following:
- Entamoeba histolytica
- Acanthamoeba lentica
- live abscesses
2. keratits in contact lens wearers (cornea stromal rings infiltrates)
how do you dx ARDS
- SEVERE refractory hypoxemia (PaO2/FI02 is less than 200mmHg that is not responsive to 100% O2)
- bilateral pulmonary infiltrates on CXR (white out pattern)
- PCWP less than 18mmHg (no cardiogenic pulm. edema)
MOA of antiemetics
- Ondansetron
- Promethazine, prochloreperazine, metoclopramide
- diphenhydramine, meclizine
- serotonin antagonists (blocks receptors)
- Dopamine blockers (blocks CNS dopamine receptors)
- antihistamine/anticholinergics (works on brains control of N/V/dizziness)
- Acute digoxin toxicity directly causes __ electrolyte abnormality
- __ electrolyte abnormality increases risk for acute dig. toxicity
HyperK
HypoK
What organism and tx for the following osteomyelitis?
- Newborn <4months:
- > 4 months:
- Sickle cell:
- Puncture wound:
*Treat 4-6 weeks w/ at least 2 weeks IV
- GBS- Tx: Nafcillin + 3rd gen cephalosporin
- S. aureus- Tx: MSSA- Nafcillin (or Oxacillin) or Cefazolin (ancef), MRSA- Vanco
- Salmonella- Tx: <18= Ceftriaxone, >18- Ciprofloxacin
- Pseduomonas- Tx: Ciprofloxacin
What are the following eye findings associated with:
- Drussen spots
- AV nicking, w/ copper or silver wiring
- teardrop or irregularly shaped pupil
- fleshy, triangular shaped growing mass on nasal side of eye
- yellow elevated nodule on nasal side of sclera that doesn’t grow
- red-rim crusting and eyelid flaking
- Arterial narrowing
- Flame shaped hemorrhages, cotton wool spots
- yellow spots w/ sharp margins often circinate
- fluffy gray-white spots
- clumping of brown-colored pigment cells in the anterior vitreous humor (tobacco dust)
- ciliary injectio, limbic flushing
- cupping of optic nerve, Steamy cornea, hard eye to palpation, halos around lights
- pale retina with cherry red macula (red spot), box car appearance of retinal vessels
- extensive retinal hemorrhages “blood and thunder” appearance, optic disc swelling
- macular degeneration
- Stage II hypertensive retinopathy
- Globe rupture
- pterygium
- pinguecula
- Blepharitis
- Stage I hypertensive retinopathy (copper= moderate, silver= severe)
- Stage III hypertensive retinopathy, DM retinopathy
- hard exudates
- cotton wool spots
- Retinal detachment (+ Shafer’s sign)
- Keratitis (corneal/ulcer) and Uveitis (iritis)
- Narrow angle closure glaucoma
- CRAO
- CRVO
SE of mannitol and acetazolamide
*act on PCT
Mannitol- pulmonary edema
Acetazolamide: kidney stones, hyperchloremic metabolic acidosis
SE of K+ sparing diuretics and special uses
- HyperK
- metabolic acidosis
- gynecomastia
Use: CHF and hyperaldosteronism
SE of sulfonamides (bactrim)
- Kernicterus if afer 2nd trimester
- sulfa allergy
- hemolysis if G6PD def.
SE of clindamycin
- C. diff
Severe, sudden unilateral ocular pain, steamy cornea, halo around lights, tunnel vision, mid-dilated fixed nonreactive pupil, hard eye, cupping of optic nerve
TX?
Acute angle closure glaucoma
TX:
1. Lower IOP (acetazolamide IV**, mannitol or topical BB)
2nd- open angle w/ cholinergics (pilocarpine or carbachol drops)-
3. Definitive tx= peripheral iridotomy
**AVOID anticholinergics and sympathomimetics
SE of Macrolides
- GI upset
- prolonged QT
- CP450 inhibition
- muscle toxicity w/ Niacin or statins
What tests correct with Mixing study
- Hemophilia A, B,
- vW disease
- Advanced liver dz
A patient is having a cervical biopsy in follow up to an abnormal pap. What is the correct management?
- LSIL (CIN I)
- HSIL (CIN II, CIN III)
- Observe if <21 or LEEP, cold knife cervical conization
2. excision (LEEP, cold knife cerivical conization) or ablation
Tx of:
- Hemophilia A (8)
- Hemophlia B (9)
- vW disease Type I
- vW disease Type II
- vW disease Type III
- Factor VIII concentrates or desmopressin
- Factor IX infusion
- mild- no tx, moderate: desmopressin, severe: DDAVP or FVIII concentrates
- DDAVP (vWF + Factor VIII prior to procedures)
- vWF + Factor VIII (DDAVP NOT HELPFUL)
What is Conn’s disease and how do you tx
- adrenal aldosteronoma that secrets aldosterone autonomously, causing hyperaldosteronism (HyperNa, hypoK)
TX: spironolactone*
Tx:
- TTP
- ITP
- HUS
- DIC
- plasmaphoresis–> steroids if severe–> splenectomy
- Kids: observe–> IVIG, Adults: steroids–> IVIG–> splenectomy
- Observe–> plamsapheresis +/- FFP (NO ABX)
- Reverse underlying cause +/- platelet transfunsion <20,000, +/- FFP
Follicular phase is __ dominant
Luteal phase is __ dominant
- __ causes follicular and egg maturation
- __ stimulates the maturing follicle to produce estrogen
- __ builds up the endometrial lining
- __ causes ovulation
- the coprus luteum secretes ___
- __ stimulates menstruation
F: Estrogen
L: Progesterone
- increased FSH: causes follicular and egg maturation
- Increased LH: stimulates the maturing follicle to produce estrogen
- estrogen: builds up the endometrial lining
- LH surge: causes ovulation
- the coprus luteum secretes: progesterone* and estrogen to maintain endometrial lining
- corpus luteum degeneration causing a fall in progesterone and estrogen levels: stimulates menstruation
Serology for
- Chronic Hep B infection
- Distant resolved Heb B infection
- acute viral hepatitis
- Window period of HepB
- Hep B vaccination
- HBsAg, - HBsAb, +HBcAb IgG, - HBe
- HBsAg, + HBsAb, + HBcAb IgG,
- HBsAg, - HBsAb, + HBcAb IgM , + HBeAg
- only + HBcAb IgM
- only + HBsAb
What fx?
- distal radius fx w/ dorsal angulation
- distal radius fx w/ ventral angulation
- prox. ulnar fx w/ anterior radial head dislocation
- mid-distal radial fx w/ dislocation of distal radioulnar joint
- Radial styloid fracture
- Ulnar shaft fx
- Colles
- Smiths
* C and S associated w/ EPL rupture - Monteggia fx
- Galeazzi fx
- Hutchinson fx or Chauffeur’s fx
- Nightstick fx
SE of Vancomycin
- Red man syndrome
- Ototoxic
- nephrotoxic
treatment of:
- restless leg syndrome
- ALS
- Guillain Barre
- Myasthenia Gravis
- Trigeminal neuralgia
- idiopathic intracranial HTN
- Dermatitis herpetiformis
- Parkinsons
- dopamine agonists ex. Pramipexole, ropinirole +/- gabapentin +/- iron supp.
- Riluzole (reduces progression for 6 mon.)
- Plasmapheresis, IVIG (prednisone is contraindicated)
- acteylcholinesterase inhibitor: pyridostigmine or neostigmine, (plasmapheresis or IVIG for myasthenic crisis)
- carbamazepine, gabapentin
- acetazolamide
- Dapsone + GF diet
- Levodopa/carbidopa– use benztropine in younger pts with predominantly tremor
Tx of
- Cryptococcosis
- Histoplasmosis
- Pneumocystis (PCP PNA)
- Brucellosis
- Q fever (coxiella burnetii)
- Plaque (Yersinia pestis)
- Camplyobacter
- Amp B + Flucystone x2wks followed by fuconazole x 10 wks
- Itraconazole or AmpB if severe
- Bactrim +/- prednisone (Dapsone-trimethoprim if sulfa allergy)
- Rifmapin + Doxy
- Doxy
- Streptomycin or gentamicin
- Erythromycin
What Abx can cause photosensitivity
- Tetracyclines
- FQ
- sulfonamides (bactrim)
- Pyrazinamide