High Grade Glioma

Question 1

HGG: TMZ dosing for HGG

Answer 1

75 mg/m2 concurrent (7 days)
150-200 mg/m2 adjuvant (days 1-5) q4 wks x 6-12 cycles

Question 2

HGG IDH wildtype: Standard RT dose

Answer 2

46 Gy to T2/FLAIR edema
Boost resection cavity ant T1 contrast enhancement to 60 Gy in 2 Gy per fx

Question 3

HGG: Follow-up after CRT

Answer 3

MRI at 2-4 weeks after

Question 4

HGG: diffuse midline glioma mutation

Answer 4

H3 K27M

Question 5

HGG: Ependymoma adult location

Answer 5

most common in the spine

Question 6

HGG: Ependymoma treatment paradigm

Answer 6

surgery +/- RT for grade 2 and above

Question 7

HGG: constraints: Optic nerve and chiasm

Answer 7

nerve < 54 Gy
Chiasm 50-54 Gy

Question 8

HGG: constraints: Spinal cord

Answer 8

45-50 Gy

Question 9

HGG: constraints: Retina

Answer 9

45 Gy

Question 10

HGG: constraints: Lens

Answer 10

10 Gy

Question 11

HGG: constraints: Inner ear

Answer 11

30 Gy, sensorineural 45-50 Gy

Question 12

HGG: constraints: Cochlea

Answer 12

50 Gy

Question 13

HGG: constraints: Epilation

Answer 13

25 Gy

Question 14

HGG: constraints: Lacrimal gland

Answer 14

Max 40 Gy
Mean 25