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Biologia Molecular > Hibridoma > Flashcards

Hibridoma Flashcards

1
Q

Quienes descubrieron la tecnología del híbridoma

A

En 1975 Koehler y milstein

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2
Q

Que es un anticuerpo monoclonal

A

Anticuerpos que vienen de una misma clona de linfocitos B y atacan el mismo epitope

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3
Q

Que son los anticuerpos policlonales

A

Son anticuerpos que vienen de más de una clona de linfocitos B y reconocen diferentes epitopes

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4
Q

Procedimiento para obtener anticuerpos monoclonales murinos

A

Inmunizar al animal
Extraer sus linfocitos del bazo
Fusionarlos con un mie loma
Cultivo de halt para que proliferen

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5
Q

Terminación de los anticuerpos murinos

A

Omab
100% murinos

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6
Q

Terminación de los anticuerpos quiméricos

A

Ximab
25 % murinos

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7
Q

Terminación de los anticuerpos humanizados

A

Zumab
90% humanos

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8
Q

Terminación de los anticuerpos humanos

A

Umab
100% humanos

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9
Q

Usos de anticuerpos monoclonales

A

Transplantes
Reumatología
Enfermedades oncológicas

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10
Q

Reacciones adversas de los anticuerpos monoclonales

A

Inmunosupresion
Reacción inmunológica exacerbada

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Biologia Molecular (10 decks)

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