HHV8

Question 1

Clinical presentations of HHV8?

Answer 1

• Multicentric Castleman’s disease
• Kaposi Sarcoma
• Primary Effusion Lymphoma
• KSHV Inflammatory Cytokine Syndrome

Question 2

Investigation of MCD/PEL?

Answer 2

Lymph node biopsy/fluid cytology . HHV 8 would be positive with LANA staining.
Serum HHV8 PCR should be raised and would be predictive if high.

Question 3

Treatment of HHV8 MCD?

Answer 3

Rituximab
Chemo

Question 4

Treatment of KS?

Answer 4

HAART

Question 5

Epidemiology of HHV8?

Answer 5

HHV-8 infection is very common in sub-Saharan Africa with seropositivity rates of over 50 percent; moderately prevalent in Mediterranean countries (20 to 30 percent); and much less common (well under 10 percent) in most of Europe, Asia, and the United States