HF formulary (pair w CCD)

Question 1

Chlorthalidone

Answer 1

-Thalitone
-12.5-50 mg
-TZD

Question 2

Dapagliflozin

Answer 2

-Forxiga
-10mg
-SGLT2

Question 3

Digoxin

Answer 3

-Digitalis/Digitec
-0.125-0.25mg

-anorexia, NV, ab pain
-visual problems
-fatigue, weakness, psychosis
-ventrivular
-AV probs
-bradycardia

Question 4

Empagliflozin

Answer 4

-Jardiance
-10mg
-SGLT2

Question 5

Furosemide

Answer 5

-Lasix
-20-40mg upto 160mg
-cut IV dose in half
-qd or BID
-loop

Question 6

Hydrochlorothiazide

Answer 6

-Esidrix or Hydrodiuril
-25-100mg
-TZD

Question 7

Hydralazine

Answer 7

-Apresoline, Dralzine
-25 mg TID/qd upto 100mg TID
-target 75mg TID

Question 8

Sacubitril/Valsartan

Answer 8

-Entresto
-49/51 mg BID if high-dose ACE upto 97/103 BID
-24/26mg BID if ACE/ARB naive, GFR <30, mod hepatic impairment, over 75 years old
-ARNI
-same SE as ACE/ARBs with hepatic impairment and within 36h of ACE/ARB use
-low Na

Question 9

Spirinolactone

Answer 9

-Aldactone
-12.5-25mg upto 25mg
-nonselective MRA
-gynecomastia, impotence, menstrual irregularities, hyperkalemia, renal fx dec
-avoid if eGFR < 30

Question 10

Toresemide

Answer 10

-Demadex
-10-20mg upto 80mg
-qd only
-loop

Question 11

Bumetanide

Answer 11

-Bumex
-0.5-1mg upto 2mg
-qd or BID
-loop

Question 12

Ivabradine

Answer 12

-Corlanor
-2.5-5mg BID upto 7.5mg BID

-fetal toxicity
-AFIB
-BRADYcardia
-CYP3A4

Question 13

Loop equivalents

Answer 13

• F 40mg = B 1mg = T 20mg

Question 14

Loop side effects

Answer 14

• dec Mg, K Na, Ca
  -dec renal fx
  -hypotension
  -inc uric acid

Question 15

TZD side effects

Answer 15

-inc Ca

Question 16

ACE contraindications/side effects

Answer 16

-CI: pregnancy, angioedema, stenosis
-hypotension
-inc K
-cough
-angioedema

Question 17

BB for HF

Answer 17

-bisoprolol 1.25mg upto 10mg (Monocor/Zebeta)
-carvedilol 3.25mg BID upto 50mg BID (Coreg)
-Cavedilol CR 10mg upto 80mg (Coreg CR)
-metoprolol CR/XL 12.5-25mg upto 200mg (Lopressor/ Torpol XL)

-monitor edema, fluid, fatigue

Question 18

Eplerenone

Answer 18

-Inspira
-25mg up to 50mg (max 25 if 30< CrCL <50)
-selective
-no antiandrogenic effects
-CYP3A4 interactions

Question 19

MRA SE

Answer 19

-inc K and Mg
-dec Na
-avoid NSAIDs and CrCl<30

Question 20

SGLT2 SE

Answer 20

-flozins
-volume depletion
-KTA in DM
-hypoglycemia
-infection risk

Question 21

ISDN

Answer 21

-Isordil
-20mg TID/qd upto 80mg TID
-40mg TID target

Question 22

ISDN/hydralazine?

Answer 22

-BiDil
-20/37.5mg TID upto 40/75mg TID

-HA
-N
-dizziness
-tachycardia, lupus
-hypotension
-inc HR
-ischemia
-fluid retention