Herpes

Question 1

What is HSV?

Answer 1

Herpes simplex virus multiplies in epithelial cells of mucosal surfaces, giving vesicles and ulcers. Lifelong infection

Question 2

what are types of HSV

Answer 2

HSV 1: tends to cause herpes labialis

HSV2: tends to cause genital herpes

Question 3

What are Sx of herpes?

Answer 3

Labialis: tingling and burning around mouth, development of vesicular then ulcerative lesions in oropharynx/perioral mucosa

Genital: asymptomatic, or tingling and burning, recurrent genital ulcerations, dysuria

Question 4

What are risk factors for HSv

Answer 4

HIV

immunocompromised

Question 5

What Ix in HSV?

Answer 5

Viral culture from swab

PCR

Question 6

What Rx for HSV?

Answer 6

Acyclovir, increase dose if recurrence, long term fo suppression

Question 7

What are complications of HSV?

Answer 7

Erythema multiforme

Keratitis

meningitis

encephalitis

Question 8

What is HZV?

Answer 8

reactivation of varicella zoster (chickenpox), causing shingles

Question 9

How does HZV reactivat

Answer 9

stays dormant in dorsal root ganglion

Question 10

What are Sx of HZV?

Answer 10

Burning and stabbing pain following by vesicular rash with itch in affected dermatome

Question 11

What are risk factors for HZV

Answer 11

Age >50, steroids, chemo, malignancy, hiv

Question 12

What Ix for hzv

Answer 12

Clinical, but can do PCr

Question 13

What ddx fo HZV

Answer 13

contact dermatitis, ulcerative keratitis, trigeminal neuralgia

Question 14

what rx for hzv

Answer 14

aciclovir

Question 15

What are complications of HZv

Answer 15

HZ ophthalmicus: if in trigeminal nerve, get eye Sx and eye ointment