Herbals Flashcards
Main use for glucosamine
Osteoarthritis
MOA for glucosamine
Normal component of cartilage matrix and synovial fluid
May prevent joint-space narrowing
Efficacy for glucosamine, chondroitin, and MSM
Glucosamine is worth a shot but will take 4-8 weeks for full effect
Chondroitin: less then glucosamine
MSM: less value (not normal human component)
Have minimal risk/SE
Dosing for glucosamine
500mg TID (or 1500mg OD)
What drug interactions does glucosamine have?
Warfarin
What is the main treatment for omega fatty acids?
Primary and secondary MI prevention
Elevated TG (cholesterol)
MOA for omega fatty acids
ALA can be converted to EPA/DHA by humans, but only minimally
We can only convert 5% of ALA to DHA/EPA
Efficacy of omega fatty acids
50/50 so can give it a try
Risk of omega fatty acids
Unlikely risk of bleeding
Unlikely mercury contamination
Dosing for omega fatty acids
1000mg fish oil = 300mg EPA/DHA
W/o CHD - 500mg/day
With CHD - 1g TID
TG lowering 2-4g/day
Drug interactions of omega fatty acids
NO agents with risk of bleeding
Natural way to get omega fatty acids
1st line: Wild salmon
Flax/flaxseed
What are the other uses for omega fatty acids
Rheumatoid arthritis
Osteoarthritis
Depression
Dry eyes
ADHD
Muscle cramps from statins
Main use for melatonin
Insomnia
MOA of melatonin
A hormone produced from tryptophan
Ties into our circadian rhythms
Efficacy of melatonin
Worth a try(actually useful)
Drug interactions for melatonin
Mild GI
Headache
Additive drowsiness with other sedating agents
Other uses for melatonin
Depression
Jet leg
CV
GERD
Antioxidant
Use of zzzquil and nytol
Insomnia
MOA of zzzquil and nytol
Using SE from 1st gen antihistamine