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GI seminar notes > hepatology > Flashcards

hepatology Flashcards

1
Q

name some liver functions

A

Bile drainage
Blood glucose
Detoxification

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2
Q

where does bilirubin come from

A

by product of haem metabolism

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3
Q

when is ALP raised

A

biliary obstruction

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4
Q

what level does alcohol raise

A

GGT

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5
Q

synthetic liver functions

A

albumin and prothrombin time

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6
Q

G6PD deficiency

A

haemolytic anaemia

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7
Q

inheritance of G6PD deficiency

A

X linked recessive

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8
Q

G6PD deficiency precipitants

A

aspirin, antimalarial, antimicrobial, infection, illness

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9
Q

how to diagnose

A

spot test

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10
Q

if only bilirubin is down where is the problem

A

prehepatic

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11
Q

examples of prehepatic causes of low bilirubin

A

sickle cell, thalassaemia

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12
Q

gilberts inheritance

A

anutosomal dominant

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13
Q

what is antinuclear antibodies positive

A

autoimmune hepatitis

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14
Q

type one autoimmune hepatitis antibodies

A

smooth muscle antibidies

ANA

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15
Q

type two autoimmune hepatitis diagnosis

A

there are no antibodies so biopsy

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16
Q

autoimmune hepatitis treatment

A

steroids and azathioprine

17
Q

ALP is raised and gamma GT raised

A

biliary obstruction

18
Q

what to do with biliary obstruction

A

do an ultrasound to see where the blockage is

19
Q

what are anti mitochondrial antibodies positive in

A

primary biliary cholangitis

20
Q

symptoms of primary biliary cholangitis

A

pruritus and tiredness

21
Q

primary biliary cholangitis common sex

A

female

22
Q

what types of disease is primary biliary cholangitis

A

autoimmune

23
Q

primary biliary cholangitis has a long

A

latent period

24
Q

most common symptom of primary biliary cholangitis

A

itching

25
Q

why do people get bone problems in primary biliary cholangitis

A

prevents calcium absorption

26
Q

Obeticholic acid treatment

A

Ursodeoxycholic acid and Obeticholic acid

27
Q

byproduct of alcohol metabolism which causes liver damage

A

Acetaldehyde

28
Q

NASH happens in

A

overweight diabetics

29
Q

how do people ed up with liver cirrosis in NASH

A

fat goes to the liver and causes inflammation

30
Q

treatment intrahepatic cholestasis in pregnancy

A

delivery

31
Q

sudden high ALT

A

paracetamol overdose

acute hepatitis

32
Q

causes of acute liver failure

A

wilsons, shock, poisoning, paracetamol, viral hepatitis

33
Q

paracetamol overdose treatment

A

N acetylcysteine

GI seminar notes (7 decks)

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