Hepatology Flashcards
quid of amebic liver disease
tender liver mass on abdominal ct scan
rx of amebic abcess
metronidazole
patient with hepatic mass after traveling in endemic areas
amebic abcess
drug causing idiosyncratic reaction hepatitis(4)
halothane
phenytoin
isoniazid
@-methyl dopa
drugs causing cholestasis(4)
chlorpromazine
erythropoietine
anabolic steroids
nitrofurantoin
drugs causing fatty liver disease(3)
tetracycline
acid valproic
ARV
drugs causing granulomatous reaction(2)
allopurinol
phenylbutazone
2 ways for drugs to cause injury
toxic effect
idiosyncratic reaction
quid of toxic effect
reaction is dose dependent
example of toxic efffect(2)
tetracycline
acetaminophen
quid of idiosyncratic effect
reaction is dose independent
example of idiosyncratic effect(2)
isoniazid
ARV
clue for non alcoholic steato hepatitis NASH(4)
non drinker
serologic hepatitis negative
obese with high ALP
slightly increase SGOT,SGPT
link to have NASH
obesity
why obesity causes NASH
fat cells are not responsive to insulin and lipid is deposited in the liver
how ‘s ALT/AST in NASH
AST/ALT<1
dx of NASH
Liver biopsy
risk factor for NASH(5)
obesity diabete hyperlipidemia parenteral nutrition medications
medication risk factor for NASH(5)
corticosteroids tamoxifen amiodarone diltiazem HAART
quid of Murphy sign
RUQ pain worst during inspiration
clue for acute cholecystitis
pain in RUQ worsen with fatty liver meal
ALP in chlocystitis
normal
where ‘s stone in acute cholecystitis
in the cystic duct
RUQ pain with high ALP(2)
cholangitis
or
choledocolithiasis
why you have fever in cholecystitis
secondary infection
why infection can happen in acute cholecystitis(2)
because of inflammatio you can have stasis and bacterial overgrowth
risk of gangrene and perforation
what’s the first step to address in case of variceal bleeding
2 large bore IV needles or central line
patien with acute pancreatitis develops palpable epigastric mass
pseudocyst formation
why amylase is elevated in pseudocyst
leak of amylase from the pseudocyst into the circulation
best image to Dx pseudocyst
US
rx of pseudocyst(2)
observation
resolve spontaneously
indication of drainage of pseudocyst(3)
more than weeks persistance
infection
> 5 cm
patient with high bilirubin direct and hgh ALP next step(3)
CT
or
US
+ antimitochondrial antibody
panacinar emphysema plus cirrhosis
@-1 antitrypsine deficiency
rx of @ antitrypsine deficiency
Alpha 1 anti trypsine factor
asymptomatic elevation of transaminase next step?
good history on risk factor
risk factor for hepatitis(5)
drug alcohol endemic area travel blod transfusion high risk sexual practices
Med causing high transaminase(5)
NSAIDS HMGco A reductase inhibitor antiepileptic drugs izoniazid herbal preparation
clue for acute pancreatitis(3)
epigastric pain
rlieve by leaning forward
occuring after binge eating
rx of acute pancreatitis(4)
conservatively
analgesics
fluid
NPO
analgesics used in acute pancreatitis(2)
fentanyl
meperidine
most common type of gallstone in US
cholesterol stone
2 types of gallstone(2)
cholesterol
calcium bilirubinate
dx of choice of cholecystitis
US abdomen
rx for symptomatic cholecystitis
laparoscopic cholecystectomy
patient with microcytic anemia and firm hepatomegaly
metastatic cancer from colon
first site for matastasis pf colon cancer
hepatic
goal standard for metastatic hepatic colon cancer
abdomen CT scan
tinding in CT during metastatic hepatic colon cancer
cholestatic syndrome
PBC clue
antimitochondrial antibody type IGM
Biopsy of PBC(2)
destruction of intrahepatic bile ducts and cholestasis
medium size bile duct
first symptom of PBC and why?(2)
pruritis
because of cholestasis
conditions associated with PBC(5)
sjogren scleroderma celiac disease autoimmiune thyroid problem hypothyroidism
drug of choice fro PBC treatment
ursodeoxycholic acid
definitive rx of PBC and severe disease
liver transplant
jews with ictere
dubin jhonson
work up for dubin jhonson(2)
Normal AST/ALT
high bilirubin conjuguee
differentiate dubin jhonson from rotor
dark granular pigment seen in hepatocytes=Dubin jhonson
mechanism of gynecomastia in cirrhosis
excess of estrogen in the body
mechanism in testicular atrophy in cirrhosis
lot
why T3T4 are low in cirrhosis
no protein to bind T3T4
why TSH is normal in cirrhosis
because you lack thyroid binding globulin not T3T4
2 causes in cirrhosis causing hypogonadism(2)
hemochromatosis
alcohol
what causes hypogonadism(2)
primary hypogonadism
secondary due to hypothalamo hypophysaire dysfuction
why lung can have problem in cirrhosis
hapatic hydrothorax
why edema in cirrhosis
low albumin level
why hepatic hydrothorax in cirrhosis
defect of diaphragm allows ascites fluid to go in pleural space
patient with cirrhosis on diuretics develops pleural fluid effusion ,next step
TIPS
transjugular porto systemic shunt
cirrhosis and shortness of breath
pleural effusion
forst rx for hepatic hydrothorax(2)
diuretic
fluid restriction
Triad of charcot(3)
ictere
fever
RUQ pain
pentad of renold(3)
triad de charcot
plus
hypotension
confusion
pentad of renold or charcot disease?
cholangitis
clue for acute cholangitis
high ALP
first step in rx of cholangitis
antibiotics
patient with cholangitis ,getting worse with antibiotics next step
surgical decompression
what’ts the best indicator of progression of HEP C infection in liver
biopsy
role of biopsy in HEP C infection(4)
stage of the disease
rule out concommitant disease
guide rx decision
surveillance
electrolyte abnormality in cirrhosis
low K+
step of management of hepatic encephalopathy(4)
supportive care
rx the precipitating cause
correct volume and electrolyte problem
lower ammonia
way to lower ammonia
lactulose
when you can add rifamixin in the rx of high ammonia in cirrhosis
when failure with lactulose after 48 h de rx
Burn Patient develops RUQ pain
acalculous cholecystitis
lactulose side effect
rifamixin
quid of acalculous cholecystitis
inflammation of gallbladder without calcul
conditions predisposing to acalculous cholecystitis(5)
severe burns severe trauma prolonged TPN prolonged fasting mechanical ventilation
complication of acalculous cholecystitis(3)
gangrene
perforation
emphysematous changes
initial work up for acalculous cholecystitis(3)
US abdomen
more specific
HIDA scan
CT scan
IV drugs user with ascites
chronic liver disease
most common cause of chronic liver disease
alcohol
hep c
why splenomegaly in cirrhosis
because of portal HTA
rx of hepatitis B preferred drug(2)
tenofovir
entecavir
drug used in rx of hep B(4)
tenofovir
entecavir
interferon
3TC
Indication of rx(6)
acute liver disease
clinical complications of cirrhosis
advanced cirrhosis with with high HBV DNA
Patient without cirrhosis but with positive HBe AG,
HBV DNA>20000< ALT AST:2f la normale
chemo or immuno suppression
why TDF and entecavir are prefered (2)
low risk of resistance
can be used in decompensated cirrhosis
cirrhosis and encephalopathy Rx
lactulose
cause of precipitation of cirrhosis(9)
infection hypoxia hypoglycemia hypovolemia porto systemic shunt excessive nitrogen load medication hypokaliemia metabolic alkalosis
medication percipitating cirrhosis
sedatives
cause of excessive nitrogen load
bleeding
4 phases in chronic infection caused by hepatitis B
immune tolerance
imune clearance
inactive carrier state
reactivatio
clue for immune tolerance(4)
high antigene HBS
High HBE antigene
high HBV replication
minimal destruction of hepatocytes
duree of immune phase
10 a 30 years
what happened in imune clearance phase
destruction of hepatocytes containing HBV
clue for this phase(2)
ALT high or normal
HBE antigene positive
meaning of HBe
active replication is occuring
what to do in the phase of ICP
serial ALT(q3-q 6 months) serial HBe Ag
why serial ALT and HBe in ICP
to fully document clearance
clue for inactive carrier(3)
Hbe ag -
Hbe aB +
Low HBV DNA
indication to conclude inactive carrier state(2)
> / a 3 Normal ALT
2 a 3 Normal HBV DNA
cue for reactivation of HepB(3)
high ALT
high HBV
fibrosis on biopsy
how to follow patient with chronic Hep B
serial ALT
what should be done to any patient with chronic hepatis
vaccination for Hep A and B
what should be done to any patient with hepatitis C infection
vaccination for Hep A and B