Hepatology 2

Question 1

What do we need to investigate before performing hepatic sampling in a liver disease case?

Answer 1

Excluding extra-hepatic causes first

Question 2

List the four indications of hepatic sampling

Answer 2

Persistent/progressive enzyme elevations
Structural parenchymal pathology
Monitoring response to therapy
Breed screening

Question 3

What should you check before performing hepatic sampling?

Answer 3

Check platelets, PT, aPTT first (+/- pre-treat with vitamin K)

Question 4

List three situations in which cholecystocentesis is contradindicated

Answer 4

Biliary obstruction
Gall bladder wall pathology
Gall bladder mucocoele

Question 5

List five situations in which surgery is indicated with liver disease

Answer 5

Abdominal free fluid
Hepatic mass lesion
Gall bladder compromise
Symptomatic gall bladder mucocoele
Obstructive biliary disease

Question 6

How would you process a hepatic biopsy specimen for histopathology?

Answer 6

In formalin

Question 7

How would you process a hepatic biopsy specimen for culture or copper quantification?

Answer 7

Fresh