Hepatology 1

Question 1

List four liver specific clinical signs

Answer 1

Icterus
Coagulopathy
Ascites
Hepatic encaphalopathy

Question 2

How would use use hepatic enzymes to determine whether liver disease is predominantly hepatocellular or cholestatic?

Answer 2

Hepatocellular - ALT and/or AST > ALP and or GGT
Cholestatic - ALP and/or GGT >ALT and/or AST

Question 3

List 8 things that may show hepatic dysfunction

Answer 3

Elevated bile acids
Elevated ammonia
Hyperbilirubinaemia
Coagulation derangements
Hypoglycaemia
Hypoalbuminaemia
Hypocholesterolaemia
Low urea

Question 4

List four common, chronic causes of primarly hepatocellular disease

Answer 4

Sterile inflamamtory
Infectious inflammatory
Neoplastic
Chronic hepatotoxin/drug exposure

Question 5

List three common causes of primarily hepatocellular disease

Answer 5

Toxic
Infectious inflammatory
Trauma

Question 6

List two infectious inflammatory causes of cholestatic liver disease

Answer 6

Neutrophilic chloangitis
Cholecystitis

Question 7

List the ALP isoenzymes

Answer 7

Cholestatic
Steroid
Bone
Drugs