hepatobiliary function Flashcards
What two receptors are on the basolateral membrane of hepatocytes to uptake bile salts? Which one is sodium dependent?
- ) NTCP
- ) OATP
NTCP
What two receptors release bile salts into the bile cannaliculi
- ) BSEP
2. ) MRP2
What transporter uptakes bile acids on the apical side of enterocytes?
ASBT
What transporter releases bile salts into the portal circulation?
OST-a and OST-b
After resection of the ileum, what happens to bile acids synthesis?
It increases
What is secretins function on bile?
It adds HCO3 and H20 to bile. It increases pH, decreases concentration of bile salts, and results in an increase in bile volume.
Secretion of bile acids is accompanied by what?
Passive movement of cations into the canaliculus
Canalicular bile is primarily an ultra filtrate of what?
Plasma
What two compounds give stool its dark color?
Stercobilin and urobilin
In heart failure, what kind of jaundice will you find and why?
Unconjugated, because the heart is not pumping bilirubin back to the liver for conjugation
In hemolytic anemia, what kind of jaundice will you find and why?
Unconjugated, because the increased amount of bilirubin overwhelms the livers ability to conjugate the bilirubin
What is the main associated symptom of criggler-najar?
kernicterus
In Dublin johnson, what color is the liver?
Black
How does phototherapy work?
Converts bilirubin into water soluble form
In rotor syndrome, what transporter is broken?
OAT-P
What are the 4 major causes of gallstone formation?
- ) Too much absorption of water from bile
- ) Too much absorption of bile acids from bile
- ) Damage to the epthelium
- ) Too much cholesterol
What do elevated AST and ALT show?
hepatocyte injury
What does elevated alkaline phosphatase show?
bile duct injury. cholestasis
