Hepatobiliary 1 Flashcards
when loss of 60-80% functional hepatic tissue occurs, ___________ results
hepatic failure
(occurs late in disease)
what are at least 5 signs of hepatic failure
decreased appetite, vomiting, lethargy, weight loss, icterus, hepatic encelopathy, abdominal effusion and/or pain, micro hepatica or hepatomegaly, fever (if infectious or bile peritonitis)
name bloodwork findings for: pre-hepatic disease
pale and icteric
anemia
name bloodwork and US findings for: hepatic disease
normal PCVC, elevated liver enzymes (ALT due to hepatocellular injury), no evidence of post-hepatic obstruction on US
name bloodwork and US findings for: post-hepatic disease
normal PCV, elevated liver enzymes (ALP, bili, GGT (cholestatic indicators)
post-hepatic obstruction on US
what is hepatic encelopathy?
NEUROLOGICAL signs arising from liver dysfunction due to accumulation of toxic byproducts (proposed toxins include AMMONIA , aromatic AAs, false NTs); the toxins accumulate due to altered hepatic clearance and metabolism
hepatic enceloppathy common therapies target decreasing _____ concentrations
ammonia
cat presents with intermittent signs of confusion, dull behaviour, head pressing, seizures and hypersalivation; these seem to be associated around mealtimes. what is your suspicion based on these C/S?
hepatic encelopathy
(mild presentation; acute severe presentation would be coma, recumbency, death)
note cats hyper salivate, not dogs
what are 3 most common HE-associated conditions in cats?
diversion of portal blood flow (congenital shunting), fulminant acute hepatic necrosis, and hepatic lipidosis
what are 3 most common HE-associated conditions in dogs?
diversion of portal blood flow (congenital shunting), fulminant acute hepatic necrosis, and reduction in hepatic mass with diversion of portal flow (acquired shunting)
how is HE treated
- Abx: neomycin, metronidazole, amoxicillin
- lactulose to trap ammonia, PO or PR
- reduced protein diet, as much protein as tolerated
- if severely affected patients: hospitalize, decrease colonic bacteria with cleansing enemas
HE treatment: what 2 things are not synthesized as much with HE
serum proteins (albumin, tpt proteins) and glycogen storage/glucose synthesis are decreased in advanced hepatic disease
ethologies of ascites
main: portal hypertension -> collagen deposition -> disorganization of parenchyma and interruption of vasculature -> increased hydrostatic pressure and acquired shunts
minor: hypoalbiminemia
note, not commonly seen in liver disease cats
fat cat was left several days without food and now is vomiting, inappetent, lethargic, dehydrated, icteric, and has palpable liver margins. what is wrong
likely hepatic lipidosis
what bloodwork and urine findings would you expect with hepatic lipidosis
bili, ALP increased, ALT moderate increase, but GGT NORMAL (or mild increase)
bilurubinuria
high albumin (dehydrated)
no inflammatory leukogram, no elevated globulins, and no fever
what is neutrophilic cholangitis
neutrophils in bile duct lumen and epithelium; can extend into parenchyma; due to ascending infection from GIT? ; can be classified as acute or chronic
