Hepato-biliary: More metabolic Flashcards
1
Q
What is NASH?
A
Advanced form of NAFLD
2
Q
Aetiology NASH
A
Metabolic syndrome - obestiy, T2DM, hypertension, hyperlipidaemia
3
Q
When is a liver considered “fatty”
A
When fat content >12%
4
Q
Sequence of events NASH
A
Steatosis (simple fatty liver)
Non-alcoholic steatohepatitis (fatty liver with inflammation)
Fibrosis (persistent inflammation)
Cirrhosis (liver covered by scar tissue) (irreversible)
5
Q
What scan can be used to assess fat content?
A
Fibroscan
6
Q
Management NASH
A
Remove causative factors: Alcohol abstinence Physical activity Weight loss Diet
7
Q
What is the chief genetic cause of liver failure in children?
A
Alpha-1 antitrypsin deficiency (cholestasis)
