Hepatitis Viruses Flashcards
Hepatitis A Genome
+ssRNA
Hep A Virion
Non-enveloped
Hep A Incubation
15-40 days
Hep A Replication
Cytoplasm
Hep A Symptoms
Jaundice
Elevated ALT levels
Hep A Transmission
Ingestion of fecally contaminated food or water
Hep A Prevalence
2nd most prevalent form of Hep A
1,987 cases in 2009
Hep A Prevention
Vaccines:
Havrix and Vaqta
Hep A Treatment
No antivirals
Hep B Genome
Circular dsDNA
Hep B Incubation
60-180 days
Hep B Replication
In the nucleus
Has an RNA intermediate
cccDNA is the template for transcription
Requires liver specific transcription factors
Hep B Symptoms
Jaundice and elevated ALT (alanine transaminase levels)
Malaise, anorexia, vomiting, fatigue, cough, serum-like sickness
Hep B Transmission
Sex and drug usage
Hep B Complications
Chronic disease occurs in 5% of cases - presence of HBsAy in blood for more than 6 months; marked by poor IgG response
There are sporadic episodes of hepatitis, cirrhosis of the liver
Increased risk for hepatocellular carcinoma
Hep B Prevalence
Most common Hepatitis infection
Hep B Prevention
Vaccination that requires multiple inoculations
Is not effective against chronic infections
Hep B Treatment
Interferon-a therapy
Nucleoside analogs
Hepatitis D
Subviral agent - rare in human viruses
Requires an active HBV infection
RNA genome encodes a single protein
Hep C Genome
(+)ssRNA
Hep C Virion
enveloped
Hep C Incubation
60-120 days
Hep C Replication
Cytoplasm
Missing cap - ribosomes recognize internal ribosome entry site
Hep C Symptoms
Jaundice, elevated ALT levels
Milder than Hep B
