Hepatitis A and B Flashcards
Hepatitis is transmitted via?
Feco-oral route
Incubation period of hepatitis A?
30 days
What does hepatitis A typically present as?
Icteric attack
Does HAV cause chronic liver disease?
No, unlike HBV and HCV
What is the lab for HAV?
antibody for HAV
Hepatitis A is associated with an elevation in both?
Serum aminotransferase and bilirubin
If bilirubin level remains elevated, what should be suspected?
Cholestaric liver disease
What is the prognosis of hepatitis A?
Complete recovery between 3 months
What is the most effective way of preventing HAV infection?
Sanitation, food safety, immunization practices
What should we give to a person after having been exposed to HAV and unvaccinated?
The HAV immunoglobulin within 2 weeks
Hepatitis B structurally is
Double-stranded DNA, unlike the RNA hepatitis A
Transmission of HBV?
parentally/vertically, or horizontally via sex
In the replication cycle of hepatitis B, cccDNA is formed, what’s that?
It serves as a template for RNA transcription
Name both characteristic histological appearances of hepatitis B
Ground-glass appearance and sanded nuclei
At what point is HBV considered to have progressed to chronic?
When HBV DNA and HBsAg persist in the serum longer than 6 months
What is FCH, fibrosing cholestatic hepatitis?
Fatal form of liver injury with recurrent HBV infection seen in Liver Transplant patients
What is FCH characterized by?
Deterioration in graft functions
What do the liver chemistry results of chronic hepatitis B show?
Abnormal results
What is the first serological marker of Acute hepatitis B?
HBsAg
When do Anti-HBs appear?
After clearance of HBsAg
In some patients there is a window period, what’s that?
When HBsAg is cleared but anti-HBs hadnt appeared, it could be months long
What is the value of Anti-HBc IgM?
Diagnoses acute hepatitis B, could be the sole marker as well during the window period
What is the biomarker that indicates HBV replication and infectivity?
HBeAg
