HEPATITIS A

Question 1

Transmission of hep A

Answer 1

Fecal oral

Question 2

HAV morphology

Answer 2

PicoRNAviridae, ss RNA, no enveloped, spheris, 27nm

Question 3

When AntiHAV emerge

Answer 3

After no detection of virus in feces

Question 4

Hep A CM?

Answer 4

Viral CM : fever, headache, arthralgia, myalgia, malaise, nausea vomitus, anorexia, diarrhea, abd pain, jaundice, clay stool, dark urine

Question 5

Hep A phase?

Answer 5

Prodormal : virus cm
Jaundice : virus cm + jaundice

Question 6

Work up for hep a?

Answer 6

IgM anti HAV, liver biochemistry : ALT, Bilirubin, ALP, PT

Question 7

DD hep a?

Answer 7

Hep b, c, drug induced, alcoholic

Question 8

Vaccination indication for hep a?

Answer 8

Age 1-18, travellers, adopting endemics children, drug user, homosexual, chronic liver disease, acceptor coagulation factor

Question 9

Treatment for hep a?

Answer 9

Nonpharmacology : symptomatic, rest until jaundice gone
Pharmacology : symptomatic

Question 10

Indication for ig hep a?

Answer 10

Below 1 y.o, chronic liver disease, more than 40 y.o, immunocompromaise

Question 11

Ig hep a dose?

Answer 11

0.02ml/kgBB IM

Question 12

Hep a complication?

Answer 12

Liver failure in 4 weeks

Question 13

How long igM anti HAV remain?

Answer 13

3 months

Question 14

When igG present?

Answer 14

during convalescent

Question 15

why HAV infection recurring every 5-20 years?

Answer 15

new segment of non-immune populations appear

Question 16

which population has more symptomatic infection?

Answer 16

adult

Question 17

HBV morphology?

Answer 17

HepaDNAvirus, DNA virus, 4 genes (S C P X), enveloped

Question 18

what receptor associated with HBV entry?

Answer 18

sodium taurocholate