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Clinical Chem II spring > Hepatitis > Flashcards

Hepatitis Flashcards

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1
Q

Non infectious hepatitis

A

radiation
chemicals
AI disease
toxins

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2
Q

infectious hepatitis

A

viral
bacterial
parastici

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3
Q

Viral hepatitis

A

most common
HAV,HBV,HCV,HDV,HEV

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4
Q

Symptoms with acute disease

A

jaundice
dark urine
vomiting
abdom pain

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5
Q

Sympt w chronic hepatitis
prolonged..

A

prolonged elevation of serum
transamine levels >6mos
seen with HBV/HCV

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6
Q

Hep A
also called?
most?
nucleotide? (n)

contaminated…
excreted in
limiting?
liver failure?

A

infectious or short Hep
most common form
NON ENVELOPED RNA
contam food/water, excreted in bile/feces (viral ag in feces)

self limiting resolves in 3wks

liverfailure rare

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7
Q

Markers to diagnose Hep A

A

IgM anti-HAV (acute infection, detect prior to sympt)

IgG-Anti-HAV soon after IgM
life long immunity

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8
Q

IgM negative and IgG pos in HEP A means?

A

past infection

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9
Q

HEP B vaccine?

A

yes vaccine for kids/travelers

RT-PCR more sensitive

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10
Q

Hep B
also called?
phases?
most..
high incidence in?
transfusions
surfaces?
bf?

A

serum hepatitis/ long incubation
acute and chronic
most ubiquitous
high incidence 25-45yrs
HBV bld transfusions rare

Can live on surface for 7days
all bf

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11
Q

Hep B high risk behaviors and routes of infection

A

high risk - sexual behavior
drug needles
immigrants

3 routes:
parenteral - eating
parinatal - preg
sexual

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12
Q

Seromarkes for HEP B
what kind of virus
site of replication?
ag synth in?

A

DNA virus
liver prim state of replication
Ag synth in nuceli of hepatocytes - cytoplasm protein coat

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13
Q

HBcAg
testing
location
during what phase

A

core of virus
no test
only presnet in nuclei of hepatocyte
during acute infection

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14
Q

HBsAG
testing of
not infectious but can
chronic carriers
complete viral clearance
ONLY MARKER
can be pos?

A

hep B surface protein
testing all infect blood units
not infect but can indicate presence
chronic carriers potentially infect
complete viral clearance pt develops ab to HBsAG

ONLY MARKER DETECTED W NEW INFECTION
can be pos 10-20dys post vacc

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15
Q

HBeAg

A

additional ag ID’d

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16
Q

HBsAb

A

suggests past infection
future immunity

+ recov from acute/chronic
aquired immunity

= not recovered/inadeq immune response

17
Q

Anti-HBc Total
differentiates?
when what things are negative?

A

diff between recent/chronic HBV
when HBsAg and Anti-HB markers are negative

18
Q

Anti-HBc IgM
pts w …have low
exacerbation

A

specific for acute HBV
pts w chronic HBV may presist at low levels
exacerbation of chronic may also test positive

19
Q

HBe Ag envelope Ag
in serum w
anti…..incidates

A

assoc w core of virus
in serum w acute/chronic
correlates w infectious particles
Anti-HBe indicates low infectivity

20
Q

HBcAg + HBsAg indicates?

A

severe course

21
Q

HBeAb

A

during recovery can be detectable
for years
low levels indicate low risk

22
Q

Chronic infection w Hep B
how many recover ?
indicator of?
how many have had since childhood?

msot effective treatment?

A

90% recover within 6 mos
indicator of Anti-HBs
25% have had since childhood

vaccination most effective

23
Q

4 phases of Hep B

A

immune tolerance
clearance
low/non replicating
reactivation

24
Q

Active replicating Hep B

A

HBeAg (+) Anti-HBe (=)

25
Q

Hep C
non..
genome?
transmission?
inapprop?

A

Non A/B hep
RNA Genome
transmitted parentally
inappr screen of blood products

26
Q

Hep C testing

A

Anti-HCV EIA
PCR for rna

27
Q

Acute Hep C

A

Acute: mild/asympt

high rate of progression to chronic cirrhosis
leading cause of transplants

28
Q

Chronic Hep C

A

high risk liver cirrhosis
safe vaccine unlikely

29
Q

Hep D
needs what to replicate

A

delta hep
defective RNA needs HBV to replicate (HBsAg)

most have HBV to have illess w hep D

30
Q

Hep E
nucleotide?
incub?
feces?
transmission?

animals?
similar to?
vaccine?

A

non envelope RNA
incub 21-42 days
feces post infect 7 days
fecal oral/waterborne

pigs/cows

similar to HAV
no vaccine

31
Q

Hep F

A

enteric
primates

32
Q

GB virus

A

infect humans no disease

33
Q

Other things that can cause hepatitis

A

Cytomegalo virus
epsteinbarr
SARS COVI 2

34
Q

Hep A
nucleotide
transmission
vaccine
chronic infection
incubation

A

RNA
2-6wk
Fecal oral
vaccine
no chronic

35
Q

Hep B
nucleotide
transmission
vaccine
chronic infection
incubation

A

DNA
8-26wk
parenteral, sexual
vaccine
chronic

36
Q

Hep C
nucleotide
transmission
vaccine
chronic infection
incubation

A

RNA
2-15
parenteral,sexual
no vaccine
chronic

37
Q

Hep D
nucleotide
transmission
vaccine
chronic infection
incubation

A

RNA
2-8
Parenteral,sexual
no vaccine
chronic

38
Q

Hep E
nucleotide
transmission
vaccine
chronic infection
incubation

A

RNA
3-6
fecal oral
no vaccine
chronic

Clinical Chem II spring (16 decks)

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