Hepatitis

Question 1

Hep A

family and genus

Answer 1

family Picornaviridase
Enterovirus | Hepatovirus

Question 2

Hep A

other names (3)

Answer 2

• short incubation hepatitis
• infectious hepatitis
• enterovirus 72

Question 3

• naked
• icosahedral
• ssRNA, 28 nm

resistant to ether, acid, heat @ 60C for 1 hour

identify.

Answer 3

Hep A

Question 4

Hep A

MOT and Incubation Period
treatment

Answer 4

fecal oral
15-45 days
average: 28 days

treatment: supportive care

Question 5

Hep A

prevention or treatment

what vaccine?

Answer 5

Twinrix
- inactivated vaccine 2 doses w/ 1 month interval

treatment of water

Question 6

Hep A

first to appear: ?
detected by solid Ab ELISA: ?

identify

Answer 6

HAV Ag first to appear
IgM anti-Hav detected by solid Ab ELISA

Question 7

Hep A

immunity detected by competitive inhibition ELISA

Answer 7

IgG anti-HAV

Question 8

enumerate the primary hepatitis

Answer 8

A, B, C, D, E, G

Question 9

enumerate the secondary hepatitis

Answer 9

• yellow fever virus
• EBV
• CMV
• HSV
• Rubella

Question 10

Hep B

family and genus

Answer 10

family Hepadnaviridae
Orthohepadnavirus

Question 11

Hep B

other names (4)

Answer 11

• Long incubation hep.
• Australian hep.
• Dane particle
• Serum hep.

Question 12

• enveloped
• icosahedral
• circular
• dsDNA, 42 nm

identify

Answer 12

Hep B

Question 13

Hep B

MOT and Incubation period

Answer 13

parenteral, perinatal, sexual
IB: 40-180 days
average: 60-90 days

Question 14

Hep B

treatment (5)

treatment / prevention

Answer 14

• supportive care
• HB immunoglobulin
• interferon
• lamivudine
• liver transplant

inactivated vaccines 3 doses

Question 15

Hep B

first marker to appear during HBV: ?
ext to appear, high infectivity: ?
no serological signifance; for liver biopsy: ?

identify

Answer 15

first marker to appear during HBV: HBsAg
ext to appear, high infectivity: HBeAg
no serological signifance; for liver biopsy: HBcAg

Question 16

Hep B

first antibody to appear: ?
lifelong marker HBV infection: ?
anti-HBs: ?
HBV DNA: ?

identify

Answer 16

first antibody to appear: IgM anti-HBc
lifelong marker HBV infection: IgG anti-HBc
anti-HBs: last to appear for immunity
HBV DNA: using PCR

Question 17

Hep B

window period

Answer 17

anti-HBc

Question 18

Hep C

family and genus

Answer 18

family FLAVIVIRIDAE
hepacivirus

Question 19

Hep C

other names (2)

Answer 19

Non-A
Non-B

Question 20

enveloped, icosahedral, linear, ssRNA, 45 nm

identify

Answer 20

Hep C

Question 21

Hep C

MOT and Incubation period

Answer 21

parenteral & sexual intercourse
IB: 30 - 50 days

Question 22

Hep C

treatment and prevention

Answer 22

• supportive care
• interferon
• ribuvirin
• liver transplant

no vaccine available

Question 23

Hep C

marker/s for diagnosis

Answer 23

anti-HCV & HCV RNA

Question 24

Hep C

symptoms

Answer 24

• jaundice
• indigestion | difficulty sleeping
• swelling of the feet and legs
• liver complications (failure or cancer)

Question 25

major cause of liver cirrhosis plus alcoholic hepatitis

Answer 25

HCV | Hep C

Question 26

# Hep D family and genus

Answer 26

family DELTAVIRIDAE **deltavirus** | also known as **defective virus | no gene or incomplete virus**

Question 27

- enveloped - circular - ssRNA, 37 nm | identify

Answer 27

Hep D

Question 28

# Hep D MOT and Incubation period

Answer 28

**parenteral, sexual intercourse, co-infection with Hep B** IP: 15 - 50 days | **HBsAg** needed by the virus

Question 29

# Hep E family and genus

Answer 29

family HEPEVIRIDAE **hepevirus** | old family and genus: **Calciviridae | Calcivirus**

Question 30

naked, icosahedral, linear, ssRNA, 30 nm | identify

Answer 30

Hep E

Question 31

# Hep E MOT and Incubation period

Answer 31

**fecal-oral route** 2-9 weeks

Question 32

# Hep E prevention and treatment

Answer 32

**no vaccine** self-limiting | supportive care

Question 33

# Hep E enumerate the markers

Answer 33

- HEV Ag - IgM anti-HEV - HEV RNA

Question 34

# Hep E IgM anti-HEV is detected by?

Answer 34

- ELISA - Western blot - Fluorescence antibody blocking assay

Question 35

# Hep E HEV RNA is detected by?

Answer 35

real time PCR

Question 36

# Hep G family and genus

Answer 36

family FLAVIVIRIDAE **flavivirus** | also known as **non-A | non-B hepatitis**

Question 37

# Hep G MOT and INCUBATION | morphology?

Answer 37

**parenteral, sexual** not established | ssRNA

Question 38

# Interpret HBsAg: **+** HBeAg: - anti-HBc: - anti-HBs: - anti-HBe: - DNA virus: **+**

Answer 38

EARLY | HBSag & DNA ra ang **positive**

Question 39

# Interpret HBsAg: **+** HBeAg: **+** anti-HBc: - anti-HBs: - anti-HBe: - DNA virus: **+**

Answer 39

ACUTE EARLY | ACUTE | postive: **HBsAg, HBeAg, DNA**

Question 40

# Interpret HBsAg: **+** HBeAg: **+** anti-HBc: **+** anti-HBs: - anti-HBe: - DNA virus: **+**

Answer 40

CHRONIC | all are positive **except anti-HBs & anti-HBe**

Question 41

# Interpret HBsAg: **+** HBeAg: - anti-HBc: +/- anti-HBs: - anti-HBe: +/- DNA virus: **+**

Answer 41

LATE ACUTE

Question 42

# Interpret HBsAg: - HBeAg: - anti-HBc: **+** anti-HBs: **+** anti-HBe: +/- DNA virus: -

Answer 42

RESOLVED | positive: **anti-HBc and anti-HBs**

Question 43

# Interpret HBsAg: - HBeAg: - anti-HBc: - anti-HBs: **+** anti-HBe: +/- DNA virus: -

Answer 43

VACCINATED | **only anti-HBs** ang positive