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Virology > Hepatitis > Flashcards

Hepatitis Flashcards

1
Q

Hep A

family and genus

A

family Picornaviridase
Enterovirus | Hepatovirus

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2
Q

Hep A

other names (3)

A
  • short incubation hepatitis
  • infectious hepatitis
  • enterovirus 72
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3
Q
  • naked
  • icosahedral
  • ssRNA, 28 nm

resistant to ether, acid, heat @ 60C for 1 hour

identify.

A

Hep A

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4
Q

Hep A

MOT and Incubation Period
treatment

A

fecal oral
15-45 days
average: 28 days

treatment: supportive care

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5
Q

Hep A

prevention or treatment

what vaccine?

A

Twinrix
- inactivated vaccine 2 doses w/ 1 month interval

treatment of water

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6
Q

Hep A

first to appear: ?
detected by solid Ab ELISA: ?

identify

A

HAV Ag first to appear
IgM anti-Hav detected by solid Ab ELISA

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7
Q

Hep A

immunity detected by competitive inhibition ELISA

A

IgG anti-HAV

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8
Q

enumerate the primary hepatitis

A

A, B, C, D, E, G

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9
Q

enumerate the secondary hepatitis

A
  • yellow fever virus
  • EBV
  • CMV
  • HSV
  • Rubella
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10
Q

Hep B

family and genus

A

family Hepadnaviridae
Orthohepadnavirus

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11
Q

Hep B

other names (4)

A
  • Long incubation hep.
  • Australian hep.
  • Dane particle
  • Serum hep.
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12
Q
  • enveloped
  • icosahedral
  • circular
  • dsDNA, 42 nm

identify

A

Hep B

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13
Q

Hep B

MOT and Incubation period

A

parenteral, perinatal, sexual
IB: 40-180 days
average: 60-90 days

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14
Q

Hep B

treatment (5)

treatment / prevention

A
  • supportive care
  • HB immunoglobulin
  • interferon
  • lamivudine
  • liver transplant

inactivated vaccines 3 doses

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15
Q

Hep B

first marker to appear during HBV: ?
ext to appear, high infectivity: ?
no serological signifance; for liver biopsy: ?

identify

A

first marker to appear during HBV: HBsAg
ext to appear, high infectivity: HBeAg
no serological signifance; for liver biopsy: HBcAg

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16
Q

Hep B

first antibody to appear: ?
lifelong marker HBV infection: ?
anti-HBs: ?
HBV DNA: ?

identify

A

first antibody to appear: IgM anti-HBc
lifelong marker HBV infection: IgG anti-HBc
anti-HBs: last to appear for immunity
HBV DNA: using PCR

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17
Q

Hep B

window period

A

anti-HBc

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18
Q

Hep C

family and genus

A

family FLAVIVIRIDAE
hepacivirus

19
Q

Hep C

other names (2)

A

Non-A
Non-B

20
Q

enveloped, icosahedral, linear, ssRNA, 45 nm

identify

21
Q

Hep C

MOT and Incubation period

A

parenteral & sexual intercourse
IB: 30 - 50 days

22
Q

Hep C

treatment and prevention

A
  • supportive care
  • interferon
  • ribuvirin
  • liver transplant

no vaccine available

23
Q

Hep C

marker/s for diagnosis

A

anti-HCV & HCV RNA

24
Q

Hep C

symptoms

A
  • jaundice
  • indigestion | difficulty sleeping
  • swelling of the feet and legs
  • liver complications (failure or cancer)
25
Q

major cause of liver cirrhosis plus alcoholic hepatitis

A

HCV | Hep C

26
Q

Hep D

family and genus

A

family DELTAVIRIDAE
deltavirus

also known as defective virus | no gene or incomplete virus

27
Q
  • enveloped
  • circular
  • ssRNA, 37 nm

identify

28
Q

Hep D

MOT and Incubation period

A

parenteral, sexual intercourse, co-infection with Hep B
IP: 15 - 50 days

HBsAg needed by the virus

29
Q

Hep E

family and genus

A

family HEPEVIRIDAE
hepevirus

old family and genus: Calciviridae | Calcivirus

30
Q

naked, icosahedral, linear, ssRNA, 30 nm

identify

31
Q

Hep E

MOT and Incubation period

A

fecal-oral route
2-9 weeks

32
Q

Hep E

prevention and treatment

A

no vaccine
self-limiting | supportive care

33
Q

Hep E

enumerate the markers

A
  • HEV Ag
  • IgM anti-HEV
  • HEV RNA
34
Q

Hep E

IgM anti-HEV is detected by?

A
  • ELISA
  • Western blot
  • Fluorescence antibody blocking assay
35
Q

Hep E

HEV RNA is detected by?

A

real time PCR

36
Q

Hep G

family and genus

A

family FLAVIVIRIDAE
flavivirus

also known as non-A | non-B hepatitis

37
Q

Hep G

MOT and INCUBATION

morphology?

A

parenteral, sexual
not established

ssRNA

38
Q

Interpret

HBsAg: +
HBeAg: -
anti-HBc: -
anti-HBs: -
anti-HBe: -
DNA virus: +

A

EARLY

HBSag & DNA ra ang positive

39
Q

Interpret

HBsAg: +
HBeAg: +
anti-HBc: -
anti-HBs: -
anti-HBe: -
DNA virus: +

A

ACUTE EARLY | ACUTE

postive: HBsAg, HBeAg, DNA

40
Q

Interpret

HBsAg: +
HBeAg: +
anti-HBc: +
anti-HBs: -
anti-HBe: -
DNA virus: +

A

CHRONIC

all are positive except anti-HBs & anti-HBe

41
Q

Interpret

HBsAg: +
HBeAg: -
anti-HBc: +/-
anti-HBs: -
anti-HBe: +/-
DNA virus: +

A

LATE ACUTE

42
Q

Interpret

HBsAg: -
HBeAg: -
anti-HBc: +
anti-HBs: +
anti-HBe: +/-
DNA virus: -

A

RESOLVED

positive: anti-HBc and anti-HBs

43
Q

Interpret

HBsAg: -
HBeAg: -
anti-HBc: -
anti-HBs: +
anti-HBe: +/-
DNA virus: -

A

VACCINATED

only anti-HBs ang positive

Virology (5 decks)

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