Heparin Flashcards
1
Q
Examples
A
LMWH
(Enoxaparin)
UFH (Unfractionated)
2
Q
MoA
A
Anti-thrombin III (ATIII) - Serine protease inhibitor
Agonist
Heparin-ATIII complex inactivates thrombin (IIa) + Xa (UFH)
Inhibits coagulation cascade
3
Q
Indications
A
Prevention + Tx of Thromboembolic disease
Prophylaxis DVT
Acute MI
4
Q
ADR
A
Bleeding (- protamine sulphate)
Hyperkalaemia
(hypoaldosteronism)
Thrombocytopenia
5
Q
Prescribing Advice
A
IV Administration
Monitoring of activated partial thromboplastin time (APTT)
X Renal failure
