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Anticoagulants > Coumarins > Flashcards

Coumarins Flashcards

1
Q

Example

A

Warfarin

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2
Q

MoA

A

Vitamin K epoxide reductase
Inhibitor
Prevents the post-translational gamma-carboxylation of factors II, VII, IX, X
Anticoagulant effect starts when formed active factors are degraded

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3
Q

Indications

A 
Tx: Thromboembolic Disease (DVT/PE)
AF
Mechanical prosthetic heart valves
TIA
Rheumatoid Heart Disease
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4
Q

ADR

A

Bleeding (- Vit K/Prothrombin)
Alopecia
Skin necrosis

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5
Q

Prescribing Advice

A

Measure the International Normalised Ratio (INR)
= ratio of patient’s PT + control sample
X Liver Disease
X Thyrotoxicosis
X Pregnancy
Decrease w/ antibiotics, Amiodarone, Cimetidine, Clofibrate, Fluconazole, Metronidazole, Antiplatelet drugs, NSAIDs
Increase w/ Barbituates, Carbamazepine, Rifampicin, Sucralfate

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Anticoagulants (4 decks)

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