Hemostasis, surgical bleeding, transfusion

Question 1

What are the major physiological events of hemostasis?

Answer 1

Vasoconstriction, platelet plug formation, fibrin formation and fibrinolysis

Question 2

What is reference range for platelets?

Answer 2

Between 150.000 to 400.000.

Question 3

Platelets role in hemostasis?

Answer 3

Form a hemostatic plug and contribute to thrombin formation. Injury to the tunica intima of vascular wall exposes collagen where platelets can adhere to. This process requires von Willebramd factor (vWF).

Question 4

Principal mediators of platelet aggregation?

Answer 4

ADP and serotonin.

Question 5

Principal mediators of platelet aggregation?

Answer 5

Serotonin and ADP

Question 6

vWF von Willebrand factor is

Answer 6

a protein involved in platelet adhesion present in blood plasma and produced in endothelium.

Question 7

Coagulation pathway can be

Answer 7

Extrinsic or intrinsic.

Question 8

Most common coagulation factor deficiencies are

Answer 8

factor VIII deficiency - hemophilia A and vW disease
factor IX deficiency - hemophilia B or Christmas disease
factor XI deficiency - hemophilia C

Question 9

Treatment for coagulation deficiency mostly is with

Answer 9

Fresh frozen plasma