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Hematology Lecture > Hemostasis > Flashcards

Hemostasis Flashcards

1
Q

Process by which the body stops bleeding only at the site of blood vessels injury and maintains blood in the FLUID STATE in the vascular compartment.

A

Hemostasis

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2
Q

2 phases of Hemostasis:

A

Primary and Secondary Hemostasis

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3
Q

Vascular and platelet response to vessel injury

A

Primary Hemostasis

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4
Q

Response of a coagulation process to such injury

A

Secondary Hemostasis

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5
Q

Activated by desquamation and small injuries to blood vessels

A

Primary Hemostasis

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6
Q

Involves vascular intima and platelets

A

Primary Hemostasis

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7
Q

Rapid, short-lived response

A

Primary Hemostasis

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7
Q

Activated by large injuries to blood vessels and surrounding tissues

A

Secondary Hemostasis

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8
Q

Involves platelets and coagulation system

A

Secondary Hemostasis

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9
Q

Delayed, long-term response

A

Secondary Hemostasis

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10
Q

Factors included in Primary Hemostasis:

A
  • Blood vessels
  • von Wilebrand factor
  • Fibrinogen
  • Calcium
  • Platelet
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11
Q

3 hemostatic components

A
  1. Extra-vascular
  2. Vascular
  3. Intra-vascular
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12
Q

Plays a part in Hemostasis by
providing back-pressure on the injured vessel through swelling and trapping of escaped blood.

A

Extra-vascular

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13
Q

Key mediator of the vasoconstriction

A

Thromboxane A2

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14
Q

Process by which blood is converted from the liquid to solid state, namely the fibrin clot.

A

Coagulation

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15
Q

Prime functions of Hemostasis

A
  • Maintain blood in fluid state
  • Arrest bleeding followed by trauma
  • remove platelet plug when healing is complete
16
Q

Steps (components) of Hemostasis

A
  1. Vasoconstriction
  2. Platelet adhesion
  3. Platelet aggregation
  4. Fibrin-platelet plug formation
  5. Fibrin stabilization
17
Q

Neurogenic response

A

Vasoconstriction

18
Q

Release of tissue thromboplastin

A

Extrinsic coagulation pathway

19
Q

Initiated by protein factors found circulating in the blood

A

Intrinsic Coagulation Pathway

20
Q

Initiated by protein factors located in the tissues

A

Extrinsic Coagulation Pathway

21
Q

Process that occurs once the fibrin clot has formed

A

Retraction

22
Q

Involves contraction and shrinkage of the fibrin strands and is induced by continued release of Factor XIII from platelets

A

Clot Retraction

22
Q

Serves to pull the edges of the damaged blood vessel together to facilitate the repair process

A

Clot retraction

23
Q

Accomplished by the enzyme plasmin that digests the fibrin
strands of the clot as well as several clotting factors.

A

Fibrinolysis or Clot dissolution

24
Q

Inhibits factor X and thrombin

A

Antithrombin III

Hematology Lecture (3 decks)

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